a Department of Communication Sciences and Disorders , Northwestern University , Evanston , IL , USA.
Cogn Neuropsychol. 2013;30(3):172-93. doi: 10.1080/02643294.2013.835717. Epub 2013 Sep 27.
Phonological processing deficits are characteristic of both the agrammatic and logopenic subtypes of primary progressive aphasia (PPA-G and PPA-L). However, it is an open question which substages of phonological processing (i.e., phonological word form retrieval, phonological encoding) are impaired in these subtypes of PPA, as well as how phonological processing deficits contribute to anomia. In the present study, participants with PPA-G (n = 7), participants with PPA-L (n = 7), and unimpaired controls (n = 17) named objects as interfering written words (phonologically related/unrelated) were presented at different stimulus onset asynchronies (SOAs) of 0, +100, +300, and +500 ms. Phonological facilitation (PF) effects (faster naming times with phonologically related interfering words) were found for the controls and PPA-L group only at SOA = 0 and +100 ms. However, the PPA-G group exhibited protracted PF effects (PF at SOA = 0, +100, and +300 ms). These results may reflect deficits in phonological encoding in PPA-G, but not in PPA-L, supporting the neuropsychological reality of this substage of phonological processing and the distinction between these two PPA subtypes.
语音处理缺陷是原发性进行性失语症（PPA-G 和 PPA-L）的语法和词聋型的特征。然而，目前仍不清楚语音处理的哪些亚阶段（即语音词形检索、语音编码）在这些 PPA 亚型中受损，以及语音处理缺陷如何导致命名障碍。在本研究中，我们让 PPA-G 组（n = 7）、PPA-L 组（n = 7）和未受损对照组（n = 17）在不同的刺激呈现时间间隔（SOA）0、+100、+300 和 +500 ms 下命名物体作为干扰的书面单词（语音相关/不相关）。只有对照组和 PPA-L 组在 SOA = 0 和 +100 ms 时出现语音促进（PF）效应（与语音相关的干扰词命名时间更快）。然而，PPA-G 组表现出持续的 PF 效应（在 SOA = 0、+100 和 +300 ms 时出现 PF）。这些结果可能反映了 PPA-G 组在语音编码方面的缺陷，但 PPA-L 组没有，这支持了语音处理这一亚阶段的神经心理学现实，以及这两种 PPA 亚型的区别。
