Epidemiology Department, Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK.
Vet J. 2013 Oct;198(1):57-69. doi: 10.1016/j.tvjl.2013.08.028. Epub 2013 Sep 4.
Laminitis is a highly debilitating disease of the foot known to have a complex and multifactorial aetiology of metabolic, inflammatory, traumatic or vascular origin. The disease has major welfare implications due to unrelenting pain associated with degenerative changes, which often necessitate euthanasia on welfare grounds. Despite this, there have been few high-quality studies investigating risk factors for equine laminitis, and only a limited number of risk factors have been previously investigated. The aim of this study was to conduct a case-control study of risk factors for active episodes of veterinary-diagnosed laminitis in horses and ponies attended by veterinary practitioners in Great Britain, based on multivariable statistical analyses. Questionnaires were received for 1010 animals, comprising 191 laminitis cases and 819 controls. Factors associated with an increased risk of laminitis were weight gain in the previous 3 months, summer and winter months compared to spring, new access to grass in the previous 4 weeks, box rest in the previous week, owner-reported history of laminitis, lameness or foot-soreness after shoeing/trimming, existing endocrinopathic (pituitary pars intermedia dysfunction and equine metabolic syndrome) disease and increasing time since the last anthelmintic treatment. Factors associated with a decreased risk of laminitis were increasing height (cm), feeding of additional supplements in the previous week and transportation in the previous week. Novel associated factors were identified that may aid in the management and prevention of the disease in the veterinary-registered equine population.
蹄叶炎是一种足部高度衰弱的疾病，已知其病因具有代谢、炎症、创伤或血管源性的复杂和多因素特征。由于与退行性变化相关的持续疼痛，该疾病对福利有重大影响，通常需要出于福利原因对动物实施安乐死。尽管如此，针对马属动物蹄叶炎的危险因素进行的高质量研究很少，而且之前只对有限数量的危险因素进行了调查。本研究旨在对英国兽医执业者诊断的马属动物活动性蹄叶炎的危险因素进行病例对照研究，该研究基于多变量统计分析。共收到 1010 个动物的问卷，包括 191 个蹄叶炎病例和 819 个对照。与蹄叶炎风险增加相关的因素包括：在过去 3 个月体重增加、与春季相比，夏季和冬季月份；在过去 4 周内新获得草地；在过去一周内进行箱式饲养；主人报告的蹄叶炎、跛行或修蹄/剪蹄后足部疼痛史；现有的内分泌疾病（垂体中间叶功能减退和马属代谢综合征）；以及自上次驱虫治疗以来的时间增加。与蹄叶炎风险降低相关的因素包括：身高增加（cm）、在过去一周内添加了额外的补充剂和在过去一周内运输。确定了新的相关因素，这些因素可能有助于管理和预防兽医注册的马属动物群体中的这种疾病。
