Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Cagliari 09124, Italy.
Molecules. 2013 Sep 25;18(10):11724-32. doi: 10.3390/molecules181011724.
Metabolomics is a new analytical technique defined as the study of the complex system of metabolites that is capable of describing the biochemical phenotype of a biological system. In recent years the literature has shown an increasing interest in paediatric obesity and the onset of diabetes and the metabolic syndrome in adulthood. Some studies show that fetal malnutrition, both excessive and insufficient, may permanently alter the metabolic processes of the fetus and increase the risk of future chronic pathologies. At present then, attention is being focused mainly on the formulation of new hypotheses, by means of metabolomics, concerning the biological mechanisms to departure from fetal-neonatal life that may predispose to the development of these diseases.
代谢组学是一种新的分析技术，定义为研究代谢物的复杂系统，能够描述生物系统的生化表型。近年来，文献对儿科肥胖和成年期糖尿病和代谢综合征的发病越来越感兴趣。一些研究表明，胎儿营养不良，无论是过多还是过少，都可能永久性地改变胎儿的代谢过程，并增加未来慢性病理的风险。目前，主要关注的是通过代谢组学提出新的假设，研究可能导致这些疾病发生的从胎儿-新生儿期开始的生物学机制。
