Limony Yehuda, Friger Michael, Hochberg Ze'ev
Migdaley-Hakenyon, P.O. Box 616, Beer Sheva 84600, Israel.
J Clin Res Pediatr Endocrinol. 2013 Sep 10;5(3):142-4. doi: 10.4274/Jcrpe.958.
Pubertal gynecomastia (PG) occurs in up to 65% of adolescent boys. In this study, we investigated the relationship between the ages at which PG and peak height velocity occur in pubertal boys.
This was a prospective study that was designed to detect PG within three months of its emergence. We examined one hundred and six boys who were followed for short stature and/or delayed puberty at three month intervals, and gynecomastia was observed in 43 of these boys (40.5%).
PG occurred in the 43 boys within a year of their peak height velocity, and most of these boys were at Tanner stage 3 for pubic hair and had testicular volumes between 8-10 mL.
It is recommended that evaluation of height growth be included in the diagnostic approach to PG in boys with short stature and/or delayed puberty. The coincidence of age of peak height velocity and PG suggests a causal relationship between the two events and a role of insulin-like growth factor-1.
青春期男性乳房发育症（PG）在高达65%的青春期男孩中出现。在本研究中，我们调查了青春期男孩中PG出现的年龄与身高增长高峰速度出现的年龄之间的关系。
这是一项前瞻性研究，旨在在PG出现后的三个月内对其进行检测。我们检查了106名因身材矮小和/或青春期延迟而接受随访的男孩，每三个月进行一次检查，其中43名男孩（40.5%）出现了男性乳房发育症。
43名男孩在身高增长高峰速度出现后的一年内出现了PG，这些男孩中的大多数阴毛处于坦纳3期，睾丸体积在8 - 10毫升之间。
建议在对身材矮小和/或青春期延迟的男孩进行PG诊断时，将身高增长评估纳入诊断方法中。身高增长高峰速度出现的年龄与PG的巧合表明这两个事件之间存在因果关系，以及胰岛素样生长因子-1的作用。
