Wang Pu, Rajian Justin R, Cheng Ji-Xin
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 USA.
J Phys Chem Lett. 2013 Jul 3;4(13):2177-2185. doi: 10.1021/jz400559a.
The quantized vibration of chemical bonds provides a way of imaging target molecules in a complex tissue environment. Photoacoustic detection of harmonic vibrational transitions provides an approach to visualize tissue content beyond the ballistic photon regime. This method involves pulsed laser excitation of overtone transitions in target molecules inside a tissue. Fast relaxation of the vibrational energy into heat results in a local temperature rise on the order of mK and a subsequent generation of acoustic waves detectable with an ultrasonic transducer. In this perspective, we review recent advances that demonstrate the advantages of vibration-based photoacoustic imaging and illustrate its potential in diagnosing cardiovascular plaques. An outlook into future development of vibrational photoacoustic endoscopy and tomography is provided.
化学键的量子化振动提供了一种在复杂组织环境中对目标分子进行成像的方法。谐波振动跃迁的光声检测提供了一种在弹道光子范围之外可视化组织成分的方法。该方法涉及对组织内目标分子的泛音跃迁进行脉冲激光激发。振动能量快速弛豫为热量会导致局部温度升高至毫开尔文量级，并随后产生可用超声换能器检测到的声波。从这个角度出发，我们回顾了近期的进展，这些进展展示了基于振动的光声成像的优势，并阐述了其在诊断心血管斑块方面的潜力。还展望了振动光声内窥镜检查和断层扫描的未来发展。
