与脑类器官研究相关的伦理问题。
Ethical issues related to brain organoid research.
机构信息
Case Western Reserve University, USA.
Case Western Reserve University, USA.
出版信息
Brain Res. 2020 Apr 1;1732:146653. doi: 10.1016/j.brainres.2020.146653. Epub 2020 Feb 1.
Abstract
This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each of these areas poses challenges for researchers, bioethicists, regulators, research institutions, and tissue banks. However, progress can be made if these parties build on past experiences with stem cell research, ethics, and policy, but adapted accordingly to new aspects of brain organoid research.
摘要
这篇综述提供了当前与人类大脑类器官研究相关的伦理问题的快照。这些问题分为以下主要主题：研究监督；人类生物材料采购和供体同意；转化交付；动物研究；以及类器官意识和道德地位。这些领域中的每一个都对研究人员、生物伦理学家、监管机构、研究机构和组织库提出了挑战。然而，如果这些方面在干细胞研究、伦理和政策方面借鉴过去的经验，并相应地适应大脑类器官研究的新方面，就可以取得进展。
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