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用于先天性膈疝的柔性胎儿镜操作系统设计

Design of a flexible fetoscopy manipulation system for congenital diaphragmatic hernia.

作者信息

Yao Wei, Elangovan Hariprashanth, Nicolaides Kypros

机构信息

Department of Biomedical Engineering, The University of Strathclyde, Glasgow, United Kingdom.

Department of Biomedical Engineering, The University of Strathclyde, Glasgow, United Kingdom.

出版信息

Med Eng Phys. 2014 Jan;36(1):32-8. doi: 10.1016/j.medengphy.2013.08.014. Epub 2013 Sep 24.

DOI:10.1016/j.medengphy.2013.08.014
PMID:24075069
Abstract

Recent advancements in fetal surgery have proven that tracheal occlusion in fetuses with congenital diaphragmatic hernia is an effective way to prevent the occurrence of pulmonary hypoplasia. A novel flexible fetoscope with a parallel mechanism structure of a thumbstick to carry on the fetal tracheal balloon occlusion by the targeting and manipulation of the fetal endoscope at a high standard of quick response and dexterity is proposed in this paper. This design is compared with a commercial rigid fetoscope in terms of operation timing and reduced stress to the fetus at neck level. Experiments using a phantom have demonstrated that the flexible fetoscope has a better dexterity and is able to perform stable tracheoscopy and balloon inflation at different levels of the trachea, with the help of a fiberoptic camera.

摘要

胎儿手术的最新进展已证明,对于患有先天性膈疝的胎儿,气管闭塞是预防肺发育不全发生的有效方法。本文提出了一种新型柔性胎儿镜,其具有拇指棒的平行机构结构,能够通过胎儿内窥镜的靶向和操作,以高标准的快速响应和灵活性进行胎儿气管球囊闭塞。在操作时机和减轻胎儿颈部压力方面,将该设计与商用刚性胎儿镜进行了比较。使用模型进行的实验表明,借助光纤摄像头,柔性胎儿镜具有更好的灵活性,能够在气管的不同水平进行稳定的气管镜检查和球囊充气。

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1
Design of a flexible fetoscopy manipulation system for congenital diaphragmatic hernia.用于先天性膈疝的柔性胎儿镜操作系统设计
Med Eng Phys. 2014 Jan;36(1):32-8. doi: 10.1016/j.medengphy.2013.08.014. Epub 2013 Sep 24.
2
Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias.鼓励开展早期临床经验,采用故意延迟的临时胎儿镜气管闭塞术对危及生命的左右先天性膈疝进行产前治疗。
Fetal Diagn Ther. 2006;21(3):314-8. doi: 10.1159/000091363.
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Comparison between fetal endoscopic tracheal occlusion using a 1.0-mm fetoscope and prenatal expectant management in severe congenital diaphragmatic hernia.严重先天性膈疝中使用 1.0mm 胎儿镜行胎儿气管镜下盲扎与产前期待治疗的比较。
Fetal Diagn Ther. 2011;29(1):64-70. doi: 10.1159/000311944. Epub 2010 Apr 10.
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Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia.
Am J Obstet Gynecol. 2001 Sep;185(3):730-3. doi: 10.1067/mob.2001.117344.
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Fetal pulmonary response after fetoscopic tracheal occlusion for severe isolated congenital diaphragmatic hernia.胎儿镜下气管阻塞术治疗严重先天性膈疝的胎儿肺脏反应。
Obstet Gynecol. 2012 Jan;119(1):93-101. doi: 10.1097/AOG.0b013e31823d3aea.
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Technical aspects of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia.胎儿内镜气管封堵术治疗先天性膈疝的技术要点。
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Evolution of a percutaneous fetoscopic access system for single-port tracheal occlusion.用于单端口气管闭塞的经皮胎儿镜接入系统的演变
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Congenital diaphragmatic hernia: prognostic indices in the fetal endoluminal tracheal occlusion era.先天性膈疝:胎儿腔内气管闭塞时代的预后指标
J Pediatr Surg. 2009 Feb;44(2):312-6. doi: 10.1016/j.jpedsurg.2008.10.078.
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Long tail balloon as a new approach for fetoscopic tracheal occlusion for a treatment of severe congenital diaphragmatic hernia.长尾球囊作为胎儿镜下气管闭塞治疗严重先天性膈疝的一种新方法。
J Obstet Gynaecol Res. 2019 Mar;45(3):719-723. doi: 10.1111/jog.13895. Epub 2019 Jan 17.
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Successful tracheal occlusion using ultrathin fetoscopic equipment combined with real-time three-dimensional ultrasound.使用超薄胎儿镜设备结合实时三维超声成功进行气管闭塞。
Eur Surg Res. 2009;43(2):204-7. doi: 10.1159/000224146. Epub 2009 Jun 10.

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