McIntyre M, Kurtz J B, Selkon J B
Public Health Laboratory, John Radcliffe Hospital, Headington, Oxford.
Epidemiol Infect. 1990 Feb;104(1):39-45. doi: 10.1017/s0950268800054509.
Sera from 252 patients with community-acquired pneumonia were examined for the presence of antibodies to 15 antigens of 7 Legionella spp. by indirect immunofluorescent antibody testing. The sera had been collected as part of the British Thoracic Society/Public Health Laboratory Service study of community-acquired pneumonia in adults. We also examined sera from 20 patients with gram-negative sepsis. Using a limited range of antigens of L. pneumophila, nine cases of legionellosis were diagnosed in the original study. However, using antigens to other Legionella spp., we identified two further cases, caused by L. micdadei and L. gormanii respectively. Twenty-six other patients had titres of 16 or 32 to one or more antigens, most commonly L. bozemanii serogroup 1, L. micdadei and L. dumoffi. None of the patients with non-legionella pneumonia, however, had significant changes in legionella antibody titres. All of the patients with Gram-negative sepsis had titres of less than 16.
通过间接免疫荧光抗体检测，对252例社区获得性肺炎患者的血清进行检测，以确定其是否存在针对7种军团菌属15种抗原的抗体。这些血清是作为英国胸科学会/公共卫生实验室服务机构对成人社区获得性肺炎研究的一部分而收集的。我们还检测了20例革兰氏阴性败血症患者的血清。在最初的研究中，使用嗜肺军团菌的有限范围抗原诊断出9例军团菌病。然而，使用针对其他军团菌属的抗原，我们又分别发现了另外2例由米克戴德军团菌和戈尔曼军团菌引起的病例。另外26例患者对一种或多种抗原的滴度为16或32，最常见的是博兹曼军团菌血清群1、米克戴德军团菌和杜莫夫军团菌。然而，非军团菌肺炎患者的军团菌抗体滴度均无显著变化。所有革兰氏阴性败血症患者的滴度均低于16。
