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蛋白质在高尔基体中的转运:囊泡运输的分子剖析

Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport.

作者信息

Rothman J E, Orci L

机构信息

Department of Molecular Biology, Princeton University, New Jersey 08544.

出版信息

FASEB J. 1990 Mar;4(5):1460-8. doi: 10.1096/fasebj.4.5.2407590.

DOI:10.1096/fasebj.4.5.2407590
PMID:2407590
Abstract

A combination of cell-free biochemical and morphological studies has revealed that a coated bud-coated vesicle transport system shuttles newly synthesized proteins through the successive processing compartments of the Golgi apparatus. These Golgi-coated vesicles operate in a manner formally analogous to the clathrin-coated, pit-coated vesicle system responsible for receptor-mediated endocytosis; however Golgi-coated vesicles do not contain clathrin.

摘要

无细胞生物化学和形态学研究相结合表明,一种有被芽-有被囊泡转运系统将新合成的蛋白质穿梭于高尔基体的连续加工区室。这些高尔基体有被囊泡的运作方式在形式上类似于负责受体介导的内吞作用的网格蛋白有被、小窝有被囊泡系统;然而,高尔基体有被囊泡不含网格蛋白。

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