尼泊尔的人类免疫缺陷病毒与丙型肝炎病毒合并感染
Human immunodeficiency virus and hepatitis C virus coinfection in Nepal.
作者信息
Barnawal Satish Prasad, Niraula Surya Raj, Agrahari Anand Kumar, Bista Nikesh, Jha Nilambar, Pokharel Paras Kumar
机构信息
School of Public Health and Community Medicine, B P Koirala Institute of Health Sciences, Dharan, Nepal.
出版信息
Indian J Gastroenterol. 2014 Mar;33(2):141-5. doi: 10.1007/s12664-013-0407-1.
OBJECTIVES
The study aimed at finding prevalence, mode of transmission, and pattern of CD4 cell count among hepatitis C virus (HCV) coinfected human immunodeficiency virus (HIV)-positive individuals in Nepal.
METHODS
This was a descriptive cross-sectional study carried out in three Volunteer Counseling and Testing clinics, one from Dharan and two from Kathmandu, Nepal. Three hundred and thirteen individuals were recruited.
RESULTS
Forty-two percent of HIV-infected persons had HCV coinfection. Significant associations with HIV and HCV coinfection were male gender (p <0.001) and injection drug use (IDU) (p <0.001). The mean CD4 cell count was significantly lower in HCV coinfected individuals, compared to those without coinfection, after 1.5 years (p =0.017), 2 years (p =0.0457), 3 years (p =0.011), and 3.5 years (p <0.001) of antiretroviral therapy.
CONCLUSION
HCV coinfection was common in HIV-infected individuals in Nepal and was associated with male gender, IDU, and lower CD4 counts.
目的
本研究旨在查明尼泊尔丙型肝炎病毒（HCV）合并感染人类免疫缺陷病毒（HIV）阳性个体的患病率、传播方式及CD4细胞计数模式。
方法
这是一项描述性横断面研究，在尼泊尔达兰的一家及加德满都的两家自愿咨询检测诊所开展。招募了313名个体。
结果
42%的HIV感染者合并感染HCV。与HIV和HCV合并感染存在显著关联的因素为男性（p<0.001）和注射吸毒（IDU）（p<0.001）。在接受抗逆转录病毒治疗1.5年（p=0.017）、2年（p=0.0457）、3年（p=0.011）和3.5年（p<0.001）后，HCV合并感染个体的平均CD4细胞计数显著低于未合并感染者。
结论
在尼泊尔，HCV合并感染在HIV感染者中很常见，且与男性、IDU及较低的CD4计数相关。
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