Curr Osteoporos Rep. 2013 Dec;11(4):263-9. doi: 10.1007/s11914-013-0168-x.
Osteoporotic fractures are associated with excess mortality and decreased functional capacity and quality of life. Age-standardized incidence rates of fragility fractures, particularly of the hip and forearm, have been noted to be decreasing in the last decade across many countries with the notable exception of Asia. The causes for the observed changes in fracture risk have not been fully identified but are likely the result of multiple factors, including birth cohort and period effects, increasing obesity, and greater use of anti-osteoporosis medications. Changing rates of fragility fractures would be expected to have an important impact on the burden of osteoporosis.
骨质疏松性骨折与过多的死亡率以及功能能力和生活质量下降有关。在过去十年中，许多国家的脆性骨折（尤其是髋部和前臂）的年龄标准化发病率都有所下降，但亚洲国家除外。观察到的骨折风险变化的原因尚未完全确定，但可能是多种因素的结果，包括出生队列和时期效应、肥胖增加以及抗骨质疏松药物的更多使用。脆性骨折发生率的变化预计将对骨质疏松症的负担产生重要影响。
