Campbell Julia Dee, Cardon Garrett, Sharma Anu
Brain and Behavior Laboratory, Speech, Language, & Hearing Sciences, 2501 Kittredge Loop Road, 409 UCB, University of Colorado, Boulder, CO 80309-0409.
Semin Hear. 2011 May 1;32(2):147-155. doi: 10.1055/s-0031-1277236.
The P1 component of the cortical auditory evoked potential (CAEP) shows clearly documented age-related decreases in latency and changes in morphology in normal hearing children, providing a biomarker for development of the auditory cortical pathways in humans. In hearing-impaired children, auditory deprivation may affect the normal age-related changes in central auditory maturation. Appropriate early intervention with amplification and/or electrical stimulation can provide the necessary stimulation needed to drive progress in central auditory maturation and auditory skill development, however objective measures are needed to evaluate the effectiveness of these treatments in infants and young children. We describe three pediatric cases, where we explored the clinical utility of the P1 as an objective biomarker of auditory cortical development after early intervention. We assessed development of P1 CAEP latency and morphology in two children with sensorineural hearing loss (SNHL) who received intervention with hearing aids (c) and cochlear implants (c) and a child with Auditory Neuropathy Spectrum Disorder (ANSD) (). Overall, we find that the P1 CAEP serves as useful tool for assessing the effectiveness of early intervention treatment and clinical management of pediatric hearing- impaired patients.
皮层听觉诱发电位（CAEP）的P1成分显示，在听力正常的儿童中，其潜伏期有明确记录的与年龄相关的缩短以及形态变化，这为人类听觉皮层通路的发育提供了一种生物标志物。在听力受损儿童中，听觉剥夺可能会影响中枢听觉成熟过程中与年龄相关的正常变化。适当的早期干预，如放大和/或电刺激，可以提供推动中枢听觉成熟和听觉技能发展所需的必要刺激，然而需要客观指标来评估这些治疗方法对婴幼儿的有效性。我们描述了三个儿科病例，在这些病例中，我们探讨了P1作为早期干预后听觉皮层发育的客观生物标志物的临床实用性。我们评估了两名感音神经性听力损失（SNHL）儿童在接受助听器（c）和人工耳蜗（c）干预后以及一名患有听觉神经病谱系障碍（ANSD）儿童（）的P1 CAEP潜伏期和形态的发育情况。总体而言，我们发现P1 CAEP是评估小儿听力受损患者早期干预治疗效果和临床管理的有用工具。
