Department of Speech, Language and Hearing Sciences, University of Colorado, Boulder, CO 80309, USA.
Int J Audiol. 2011 Feb;50(2):98-106. doi: 10.3109/14992027.2010.542492.
OBJECTIVE. Auditory neuropathy spectrum disorder (ANSD) affects approximately 10% of patients with sensorineural hearing loss. While many studies report abnormalities at the level of the cochlea, auditory nerve, and brainstem in children with ANSD, much less is known about their cortical development. We examined central auditory maturation in 21 children with ANSD. DESIGN. Morphology, latency and amplitude of the P1 cortical auditory evoked potential (CAEP) were used to assess auditory cortical maturation. Children's scores on a measure of auditory skill development (IT-MAIS) were correlated with CAEPs. Study Sample. Participants were 21 children with ANSD. All were hearing aid users.
Children with ANSD exhibited differences in central auditory maturation. Overall, two-thirds of children revealed present P1 CAEP responses. Of these, just over one third (38%) showed normal P1 response morphology, latency and amplitude, while another third (33%) showed delayed P1 response latencies and significantly smaller amplitudes. The remaining children (29%) revealed abnormal or absent P1 responses. Overall, P1 responses were significantly correlated with auditory skill development.
Our results suggest that P1 CAEP responses may be: (i) A useful indicator of the extent to which neural dys-synchrony disrupts cortical development, (ii) A good predictor of behavioral outcome in children with ANSD.
目的。听觉神经病谱系障碍（ANSD）影响大约 10%的感音神经性听力损失患者。虽然许多研究报告了 ANSD 儿童耳蜗、听神经和脑干水平的异常，但对其皮质发育的了解要少得多。我们检查了 21 名 ANSD 儿童的中枢听觉成熟情况。设计。使用 P1 皮质听觉诱发电位（CAEP）的形态、潜伏期和振幅来评估听觉皮质成熟。儿童的听觉技能发展（IT-MAIS）测量得分与 CAEPs 相关。研究样本。参与者为 21 名 ANSD 儿童。他们都是助听器使用者。
ANSD 儿童的中枢听觉成熟存在差异。总体而言，三分之二的儿童显示出 P1 CAEP 反应。其中，超过三分之一（38%）的儿童表现出正常的 P1 反应形态、潜伏期和振幅，而三分之一（33%）的儿童表现出 P1 反应潜伏期延迟和显著较小的振幅。其余儿童（29%）显示出异常或不存在 P1 反应。总体而言，P1 反应与听觉技能发展显著相关。
我们的结果表明，P1 CAEP 反应可能是：（i）神经不同步对皮质发育的破坏程度的有用指标，（ii）ANSD 儿童行为结果的良好预测指标。
