儿童炎症性肠病中与健康相关生活质量的关联因素：一种累积风险模型方法。
Correlates of health-related quality of life in pediatric inflammatory bowel disease: a cumulative risk model approach.
作者信息
Gumidyala Amitha Prasad, Greenley Rachel Neff
机构信息
MS, Department of Psychology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
出版信息
J Pediatr Psychol. 2014 Jan-Feb;39(1):55-64. doi: 10.1093/jpepsy/jst073. Epub 2013 Sep 26.
OBJECTIVE
To examine associations between disease-related, individual, and contextual risk factors and health-related quality of life (HRQoL) in a sample of youth with inflammatory bowel disease using a cumulative risk model framework.
METHODS
Participants were 50 youth (58% male; M age = 15 years). Youth and parents completed measures of HRQoL, psychological functioning, and family functioning. Disease information was collected from medical record reviews. Medication adherence was electronically monitored via MEMS cap bottles. A cumulative risk index (CRI) was constructed based on disease activity, disease type, gender, anxiety/depression, medication adherence, general family functioning, disease-specific family functioning, and socioeconomic status.
RESULTS
The CRI was associated with all youth- and mother-reported HRQoL domains. Furthermore, contextual domain factors were most consistently associated with youth and maternal reports of HRQoL.
CONCLUSION
These results show promise in supporting the value of the CRI in identifying potential risk factors for lower HRQoL in a cross-sectional sample.
目的
使用累积风险模型框架，在一组患有炎症性肠病的青少年样本中，研究疾病相关、个体和环境风险因素与健康相关生活质量（HRQoL）之间的关联。
方法
参与者为50名青少年（58%为男性；平均年龄 = 15岁）。青少年及其父母完成了HRQoL、心理功能和家庭功能的测量。通过病历审查收集疾病信息。通过MEMS瓶盖对药物依从性进行电子监测。基于疾病活动、疾病类型、性别、焦虑/抑郁、药物依从性、一般家庭功能、疾病特异性家庭功能和社会经济地位构建累积风险指数（CRI）。
结果
CRI与所有青少年和母亲报告的HRQoL领域相关。此外，环境领域因素与青少年和母亲报告的HRQoL最一致相关。
结论
这些结果有望支持CRI在识别横断面样本中HRQoL较低的潜在风险因素方面的价值。
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