Chung Hsu-Ming, Wang Wei-Hsien, Hwang Tsong-Long, Wu Yang-Chang, Sung Ping-Jyun
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Nat Prod Commun. 2013 Aug;8(8):1037-40.
Three natural clovane-related sesquiterpenoids, 2beta-acetoxyclovan-9alpha-ol (1), 9alpha-acetoxyclovan-2beta-ol (2) and clovan-2beta,9beta-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
从柳珊瑚反口拟柳珊瑚（Rumphella antipathies）中分离出了三种与菖蒲烷相关的天然倍半萜类化合物，即2β-乙酰氧基菖蒲烷-9α-醇（1）、9α-乙酰氧基菖蒲烷-2β-醇（2）和菖蒲烷-2β,9β-二醇（3）。通过光谱方法并将光谱数据与已知菖蒲烷类似物的数据进行比较，阐明了菖蒲烷1-3的结构。这是首次从天然来源分离出菖蒲烷1-3。菖蒲烷1和2对人中性粒细胞中超氧阴离子的产生和弹性蛋白酶的释放具有抑制作用。
