Liu Yu, Yin Zhong-Qiong, Wei Qin, Jia Ren-Yong, Fan Jing, Zhou Li-Jun, Du Yong-Hua
College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(13):2105-8.
To study the optimum preparation process and stability of beta-cyclodextrin inclusion compound in volatile oil of Cinnamomum longepaniculatum leaves. The saturated aqueous solution method was adopted to prepare inclusion compounds for an orthogonal test. The inclusion compound productivity and the inclusion rate were taken as indexes for screening the inclusion processes. The inclusion effect was evaluated with the infrared spectrophotometry and TLC, and the stability under conditions of high temperature, high humidity and strong light was detected. Under optimum preparation conditions for inclusion, the ratio between volatile oil and beta-cyclodextrin was 1: 8 (mL: g), that between beta-cyclodextrin and water was 1: 15, the inclusion temperature was 40 degrees C, and the inclusion time was 3 h. The results of spectrophotometry and TLC showed that the optimum conditions can generate beta-cyclodextrin inclusion compound in volatile oil of C. longepaniculatum leaves with certain light resistance, thermo-stability and hygro-stability. Therefore the optimum inclusion process features simple operation and stable inclusion compounds.
研究长柄樟叶挥发油β-环糊精包合物的最佳制备工艺及稳定性。采用饱和水溶液法制备包合物并进行正交试验，以包合物得率和包合率为指标筛选包合工艺，通过红外分光光度法和薄层色谱法评价包合效果，检测其在高温、高湿、强光条件下的稳定性。在最佳包合制备条件下，挥发油与β-环糊精的比例为1:8（mL:g），β-环糊精与水的比例为1:15，包合温度为40℃，包合时间为3 h。分光光度法和薄层色谱法结果表明，最佳条件下可制得具有一定耐光性、热稳定性和吸湿性的长柄樟叶挥发油β-环糊精包合物。因此，该最佳包合工艺操作简便，包合物稳定。
