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基于核磁共振代谢组学探索人乳成分。

Exploring human breast milk composition by NMR-based metabolomics.

机构信息

a Department of Chemistry , Sapienza University of Rome , p.le Aldo Moro 5, 00185 Rome , Italy.

出版信息

Nat Prod Res. 2014;28(2):95-101. doi: 10.1080/14786419.2013.843180. Epub 2013 Oct 1.

DOI:10.1080/14786419.2013.843180
PMID:24079341
Abstract

Breast milk is a complex fluid evolutionarily adapted to satisfy the nutritional requirements of growing infants. In addition, milk biochemical and immunological components protect newborns against infective agents in the new environment. Human milk oligosaccharides, the third most abundant component of breast milk, are believed to modulate the microbiota composition, thus influencing a wide range of physiological processes of the infant. Human milk also contains a number of other bioactive compounds, the functional role of which has not yet been clearly elucidated. In this scenario, NMR-based metabolic profiling can provide a rapid characterisation of breast milk composition, thus allowing a better understanding of its nutritional properties.

摘要

母乳是一种复杂的液体,经过进化以满足不断成长的婴儿的营养需求。此外,牛奶的生化和免疫成分可以保护新生儿免受新环境中的感染源的侵害。人乳寡糖,母乳中第三丰富的成分,被认为可以调节微生物群的组成,从而影响婴儿的广泛生理过程。母乳还含有许多其他生物活性化合物,其功能作用尚未明确阐明。在这种情况下,基于 NMR 的代谢组学可以快速描述母乳的成分,从而更好地了解其营养特性。

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