三维重建识别出肺静脉错位为肺泡毛细血管发育不良的肺内分流血管。
Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia.
机构信息
Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Division of Nephrology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
出版信息
J Pediatr. 2014 Jan;164(1):192-5. doi: 10.1016/j.jpeds.2013.08.035. Epub 2013 Sep 27.
Abstract
Alveolar capillary dysplasia (ACD) with misalignment of pulmonary veins (MPV) is a lethal neonatal lung disease. Death from ACD/MPV is caused by hypoxia, but the role of the MPV is unknown. Using 3-dimensional reconstruction of ACD/MPV lung tissue, we report that the veins in MPV are intrapulmonary shunt vessels, and speculate that MPV contributes to the poor prognosis.
摘要
肺泡毛细血管发育不良（ACD）伴肺静脉异位（MPV）是一种致命的新生儿肺部疾病。ACD/MPV 导致的死亡是由缺氧引起的，但 MPV 的作用尚不清楚。通过对 ACD/MPV 肺部组织的三维重建，我们报告了 MPV 中的静脉是肺内分流血管，并推测 MPV 导致了不良预后。
相似文献
1
Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia.三维重建识别出肺静脉错位为肺泡毛细血管发育不良的肺内分流血管。
J Pediatr. 2014 Jan;164(1):192-5. doi: 10.1016/j.jpeds.2013.08.035. Epub 2013 Sep 27.
2
Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins.肺静脉排列异常所致肺泡毛细血管发育不良中的肺内血管分流途径
Thorax. 2015 Jan;70(1):84-5. doi: 10.1136/thoraxjnl-2014-205851. Epub 2014 Jul 21.
3
Synchrotron-based phase-contrast micro-CT as a tool for understanding pulmonary vascular pathobiology and the 3-D microanatomy of alveolar capillary dysplasia.基于同步加速器的相衬 micro-CT 作为一种了解肺血管病理生物学和肺泡毛细血管发育不良的三维微观解剖结构的工具。
Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L65-L75. doi: 10.1152/ajplung.00103.2019. Epub 2019 Oct 9.
4
Histopathologic features of alveolar capillary dysplasia with misalignment of pulmonary veins with atypical clinical presentation.肺泡毛细血管发育不良伴肺静脉错位的组织病理学特征，伴有非典型临床表现。
Cardiovasc Pathol. 2021 Jan-Feb;50:107289. doi: 10.1016/j.carpath.2020.107289. Epub 2020 Sep 16.
5
A Novel De Novo Pathogenic Variant in FOXF1 in a Newborn with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins.一名患有肺泡毛细血管发育不良伴肺静脉错位的新生儿中FOXF1基因的一种新型新生致病性变异
Yonsei Med J. 2017 May;58(3):672-675. doi: 10.3349/ymj.2017.58.3.672.
6
De Novo mutation of FOXF1 causes alveolar capillary dysplasia with misalignment of pulmonary veins: A case report.FOXF1 新生突变导致肺静脉错位的肺泡毛细血管发育不良：病例报告。
Medicine (Baltimore). 2021 Apr 9;100(14):e25375. doi: 10.1097/MD.0000000000025375.
7
Two autopsy cases of siblings with alveolar capillary dysplasia: clinical and post-mortem issues.两例肺泡毛细血管发育不良的同胞兄妹尸检病例：临床和死后问题。
Forensic Sci Med Pathol. 2020 Mar;16(1):180-183. doi: 10.1007/s12024-019-00153-y. Epub 2019 Sep 11.
8
Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia.严重支气管肺发育不良中三维重建的肺内吻合的组织学证据。
Ann Am Thorac Soc. 2013 Oct;10(5):474-81. doi: 10.1513/AnnalsATS.201305-124OC.
9
Alveolar capillary dysplasia with misalignment of the pulmonary veins: A surgical lung biopsy and autopsy in a full-term newborn.肺泡毛细血管发育不良伴肺静脉异位连接：一例足月新生儿的外科肺活检和尸检。
Rev Esp Patol. 2024 Oct-Dec;57(4):305-308. doi: 10.1016/j.patol.2024.06.005. Epub 2024 Jul 23.
10
Twins with alveolar capillary dysplasia with misalignment of pulmonary veins: Strategies for diagnosis and management.患有肺静脉排列异常的肺泡毛细血管发育不良的双胞胎：诊断与管理策略
J Neonatal Perinatal Med. 2024;17(1):147-152. doi: 10.3233/NPM-230085.
引用本文的文献
1
The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure.心力衰竭患者混合静脉血氧饱和度与肺动脉压和肺静脉压的关系。
Physiol Rep. 2024 Nov;12(22):e70128. doi: 10.14814/phy2.70128.
2
Innovations in Childhood Interstitial and Diffuse Lung Disease.儿童间质性和弥漫性肺病的创新。
Clin Chest Med. 2024 Sep;45(3):695-715. doi: 10.1016/j.ccm.2024.04.002.
3
Childhood interstitial lung diseases: current understanding of the classification and imaging findings.儿童间质性肺疾病：分类和影像学表现的最新认识。
Jpn J Radiol. 2024 Sep;42(9):937-952. doi: 10.1007/s11604-024-01603-6. Epub 2024 Jul 16.
4
Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.单细胞多组学鉴定肺泡毛细血管发育不良相关细胞和遗传网络。
Am J Respir Crit Care Med. 2023 Sep 15;208(6):709-725. doi: 10.1164/rccm.202210-2015OC.
5
Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants.血管内皮生长因子作为预防极低出生体重儿支气管肺发育不良的分子靶点。
Int J Mol Sci. 2023 Feb 1;24(3):2729. doi: 10.3390/ijms24032729.
6
Rare to "Ubiquitinous": Alveolar Capillary Dysplasia, FOXF1, and a Sly Approach to Angiogenesis.从“罕见”到“普遍存在”：肺泡毛细血管发育不良、FOXF1 以及一种对血管生成的巧妙研究方法
Am J Respir Crit Care Med. 2023 Apr 15;207(8):969-971. doi: 10.1164/rccm.202212-2273ED.
7
High-level gonosomal mosaicism for a pathogenic non-coding CNV deletion of the lung-specific FOXF1 enhancer in an unaffected mother of an infant with ACDMPV.在一名患有 ACDMPV 的婴儿的未受影响的母亲中，存在高水平的性腺嵌合体，该嵌合体携带肺特异性 FOXF1 增强子的致病性非编码 CNV 缺失。
Mol Genet Genomic Med. 2022 Nov;10(11):e2062. doi: 10.1002/mgg3.2062. Epub 2022 Sep 20.
8
Interstitial lung disease in infancy and early childhood: a clinicopathological primer.婴儿和幼儿期的间质性肺病：临床病理基础。
Eur Respir Rev. 2022 Mar 9;31(163). doi: 10.1183/16000617.0251-2021. Print 2022 Mar 31.
9
A Step toward Treating a Lethal Neonatal Lung Disease. STAT3 and Alveolar Capillary Dysplasia.迈向治疗一种致命性新生儿肺部疾病的一步。信号转导和转录激活因子3与肺泡毛细血管发育异常
Am J Respir Crit Care Med. 2019 Oct 15;200(8):961-962. doi: 10.1164/rccm.201906-1102ED.
10
Clinical, Histopathological, and Molecular Diagnostics in Lethal Lung Developmental Disorders.致命性肺发育障碍的临床、组织病理学和分子诊断学
Am J Respir Crit Care Med. 2019 Nov 1;200(9):1093-1101. doi: 10.1164/rccm.201903-0495TR.
本文引用的文献
1
Analysis of 3D branching pattern: hematoxylin and eosin method.三维分支模式分析：苏木精-伊红染色法
Methods Mol Biol. 2012;886:73-86. doi: 10.1007/978-1-61779-851-1_7.
2
Alveolar capillary dysplasia.肺泡毛细血管发育不良。
Am J Respir Crit Care Med. 2011 Jul 15;184(2):172-9. doi: 10.1164/rccm.201010-1697CI. Epub 2011 Mar 11.
3
Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations.16号染色体长臂24.1区域FOX基因簇的基因组和基因缺失以及FOXF1的失活突变会导致肺泡毛细血管发育异常和其他畸形。
Am J Hum Genet. 2009 Jun;84(6):780-91. doi: 10.1016/j.ajhg.2009.05.005. Epub 2009 Jun 4.
4
Alveolar capillary dysplasia: a six-year single center experience.肺泡毛细血管发育不良：六年单中心经验
J Perinat Med. 2005;33(4):347-52. doi: 10.1515/JPM.2005.067.
5
Pulmonary arteriovenous shunting in the normal fetal lung.
J Am Coll Cardiol. 2004 Oct 6;44(7):1497-500. doi: 10.1016/j.jacc.2004.06.064.
6
Alveolar capillary dysplasia: diagnostic potential for cardiac catheterization.肺泡毛细血管发育不良：心导管检查的诊断潜力
J Perinatol. 1999 Sep;19(6 Pt 1):441-6. doi: 10.1038/sj.jp.7200243.
7
Combined therapy with inhaled nitric oxide and intravenous prostacyclin in an infant with alveolar-capillary dysplasia.
Am J Respir Crit Care Med. 1997 Feb;155(2):743-6. doi: 10.1164/ajrccm.155.2.9032222.
8
Dilated bronchial veins within pulmonary parenchyma. Observatins in congenital pulmonary venous obstruction.
Arch Pathol. 1971 Mar;91(3):256-60.
9
A case of pulmonary veno-occlusive disease and a new bronchoscopic sign.
Respir Med. 1990 Nov;84(6):503-5. doi: 10.1016/s0954-6111(08)80117-5.
10
Persistent pulmonary hypertension of the newborn due to alveolar capillary dysplasia.
Pediatr Pathol. 1992 Jul-Aug;12(4):499-514. doi: 10.3109/15513819209024200.
Zotero 插件