Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, Aarhus - C, DK8000 Denmark.
Curr Pharm Des. 2014;20(18):3036-9. doi: 10.2174/13816128113196660708.
The science and study of the biological basis of aging, biogerontology, is now a well-established field with solid scientific base. A paradigm-shift in gerontology has occurred by realising the fact that biological aging occurs in spite of the presence of complex homeodynamic pathways of maintenance, repair and defence, and there is no "enemy within". This viewpoint separates the modulation of aging from the treatment of one or more age-related diseases. A promising strategy in biogerontology is to slow down aging and to extend healthspan by hormetin-mediated hormesis. Physical, nutritional and mental hormetins, which initiate stress responses and strengthen the homeodynamics, are potentially effective aging modulators. As a biomedical issue, the biological process of aging underlies all major diseases, and while the optimal treatment of every disease is a social and moral necessity, preventing the onset of agerelated diseases by intervening in the basic process of aging is the best approach for designing novel pharmaceutical interventions.
衰老的生物学基础的科学和研究，即生物老年学，现在已经是一个成熟的领域，具有坚实的科学基础。通过认识到尽管存在复杂的内稳性维持、修复和防御途径，但生物衰老仍然会发生，而且没有“内在敌人”，老年学发生了范式转变。这种观点将衰老的调节与一种或多种与年龄相关的疾病的治疗区分开来。生物老年学中一个有前途的策略是通过代谢激活剂介导的应激反应来减缓衰老并延长健康寿命。物理、营养和精神应激原会引发应激反应并增强内稳性，它们可能是有效的衰老调节剂。作为一个生物医学问题，衰老的生物学过程是所有主要疾病的基础，虽然对每种疾病的最佳治疗都是一种社会和道德上的必要，但通过干预衰老的基本过程来预防与年龄相关的疾病是设计新型药物干预措施的最佳方法。
