Biological Sciences and Bioengineering Program, Sabanci University, 34956, Tuzla, Istanbul, Turkey.
Curr Pharm Des. 2014;20(18):3052-67. doi: 10.2174/13816128113196660702.
Aging is a stage of life of all living organisms. According to the free-radical theory, aging cells gradually become unable to maintain cellular homeostasis due to the adverse effects of reactive oxygen species (ROS). ROS can cause irreversible DNA mutations, protein and lipid damage which are increasingly accumulated in the course of time if cells could not overcome these effects by the antioxidant defence system. Accrued damaged molecules in cells may either induce cellular death or contribute to develop various pathologies. Hence, programmed cell death mechanisms, apoptosis and autophagy, play a vital role in the aging process. Although they are strictly controlled by various interconnected signalling pathways, alterations in their regulations may contribute to severe pathologies including cancer, Alzheimer's and Parkinson's diseases. In this review, we summarized our current understanding and hypotheses regarding oxidative stress and age-related dysregulation of cell death signalling pathways.
衰老是所有生物生命阶段中的一个阶段。根据自由基理论，衰老细胞由于活性氧（ROS）的不利影响，逐渐变得无法维持细胞内稳态。如果细胞不能通过抗氧化防御系统克服这些影响，ROS 会导致 DNA 突变、蛋白质和脂质损伤的不可逆转，这些损伤会随着时间的推移而不断积累。细胞中累积的受损分子可能导致细胞死亡，或者导致各种病理的发生。因此，程序性细胞死亡机制，细胞凋亡和自噬，在衰老过程中起着至关重要的作用。尽管它们受到各种相互关联的信号通路的严格控制，但它们的调节变化可能导致严重的病理，包括癌症、阿尔茨海默病和帕金森病。在这篇综述中，我们总结了我们对氧化应激和与年龄相关的细胞死亡信号通路失调的理解和假设。
