Zhang Xiaolian, Lu Yu, Rong Chengzhi, Yang Dongmei, Li Shan, Qin Xue
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
J Res Med Sci. 2016 Oct 18;21:94. doi: 10.4103/1735-1995.192510. eCollection 2016.
Reactive oxygen species (ROS) play important roles in hepatocarcinogenesis. Superoxide dismutase (SOD) is involved in the repair of ROS. Serum alpha-fetoprotein (AFP) is the "golden marker" for diagnosing hepatocellular carcinoma (HCC), and one major shortcoming of its use is that it is insensitive for the early detection of HCC. Therefore, we evaluated serum SOD levels and their association with AFP in hepatitis B virus (HBV)-related HCC.
A total of 279 subjects were divided into three groups: 99 HBV patients with HCC, 73 HBV patients without HCC, and 107 sex- and age-matched healthy controls. Serum levels of SOD were assayed using colorimetry, while AFP levels were measured by electrochemiluminescence immunoassay.
A highly significant elevation was found in AFP in HBV-with HCC patients compared to HBV-without HCC patients and control subjects ( < 0.001). Alternatively, serum SOD levels were significantly decreased in patients with HCC compared to HBV patients without HCC and healthy controls ( < 0.001). Furthermore, serum SOD was negatively correlated with AFP ( = -0.505, < 0.001) in HBV-with HCC patients.
SOD and AFP might be simultaneously evaluated to improve the HCC detection rate.
活性氧（ROS）在肝癌发生过程中起重要作用。超氧化物歧化酶（SOD）参与ROS的修复。血清甲胎蛋白（AFP）是诊断肝细胞癌（HCC）的“金标准”，但其主要缺点是对HCC的早期检测不敏感。因此，我们评估了乙型肝炎病毒（HBV）相关HCC患者的血清SOD水平及其与AFP的相关性。
共279名受试者分为三组：99例HBV相关HCC患者、73例无HCC的HBV患者和107例年龄和性别匹配的健康对照。采用比色法检测血清SOD水平，用电化学发光免疫分析法检测AFP水平。
与无HCC的HBV患者和健康对照相比，HBV相关HCC患者的AFP显著升高（<0.001）。相反，与无HCC的HBV患者和健康对照相比，HCC患者的血清SOD水平显著降低（<0.001）。此外，在HBV相关HCC患者中，血清SOD与AFP呈负相关（=-0.505，<0.001）。
可同时评估SOD和AFP以提高HCC的检出率。
