Zhang C T, Shi D, Zheng Y, Zheng C Y, Li Q H
Department of Clinical Pharmacy, College of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China.
Indian J Pharm Sci. 2013 May;75(3):357-61. doi: 10.4103/0250-474X.117407.
Puerarin injection has been widely used for clinic treatment of diabetes recently. To assess the relationship between the administration time of puerarin and the blood concentration of puerarin as well as its pharmacokinetic parameters, the diabetic rat model was used in current study. The rats were randomly divided into morning and evening groups according to the administration time. After the puerarin injection, blood glucose was tested in order to know whether the efficiency of puerarin was influenced by its concentration and pharmacokinetic parameters. Our results show that the average concentration of puerarin in the evening group is significantly higher than that in the morning group. The numbers of t1/2α, t1/2β, CL and AUC(0-∞) are significantly different between the morning and evening groups. The blood glucose level in the evening group was lower than that in the morning group. The speed of its onset is higher and the blood glucose level declines much more significantly in the evening group. These findings suggest that the concentration and pharmacokinetic parameters of puerarin affect its efficiency in diabetic rats. Therefore, it might be better to give puerarin in evening than in the morning for the mellitus treatment.
葛根素注射液近年来已广泛应用于糖尿病的临床治疗。为评估葛根素给药时间与葛根素血药浓度及其药代动力学参数之间的关系，本研究采用糖尿病大鼠模型。根据给药时间将大鼠随机分为上午组和晚上组。注射葛根素后，检测血糖，以了解葛根素的疗效是否受其浓度和药代动力学参数的影响。我们的结果表明，晚上组葛根素的平均浓度显著高于上午组。上午组和晚上组的t1/2α、t1/2β、CL和AUC(0-∞)数值有显著差异。晚上组的血糖水平低于上午组。其起效速度更快，晚上组的血糖水平下降更为显著。这些发现表明，葛根素的浓度和药代动力学参数影响其对糖尿病大鼠的疗效。因此，对于糖尿病治疗，晚上给予葛根素可能比上午给药更好。
