袋獾面部肿瘤疾病是如何逃避宿主免疫反应的。
How the devil facial tumor disease escapes host immune responses.
作者信息
Siddle Hannah V, Kaufman Jim
机构信息
University of Cambridge; Department of Pathology; Cambridge, UK.
出版信息
Oncoimmunology. 2013 Aug 1;2(8):e25235. doi: 10.4161/onci.25235. Epub 2013 Jun 10.
Abstract
The devil facial tumor disease (DFTD) is a contagious cancer that has recently emerged among Tasmanian devils, rapidly decimating the population. We have recently discovered that DFTD cells lose the expression MHC molecules on the cell surface, explaining how this tumor avoids recognition by host CD8 T cells.
摘要
袋獾面部肿瘤疾病（DFTD）是一种传染性癌症，最近在袋獾中出现，迅速导致种群数量锐减。我们最近发现，DFTD细胞会丧失细胞表面MHC分子的表达，这就解释了这种肿瘤是如何逃避宿主CD8 T细胞识别的。
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