Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Calcutta 700054, West Bengal, India.
Food Chem Toxicol. 2013 Dec;62:584-600. doi: 10.1016/j.fct.2013.09.026. Epub 2013 Sep 29.
Exposure to environmental pollutants and drugs can result in pathophysiological situations in the body. Research in this area is essential as the knowledge on cellular survival and death would help in designing effective therapeutic strategies that are needed for the maintenance of the normal physiological functions of the body. In this regard, naturally occurring bio-molecules can be considered as potential therapeutic targets as they are normally available in commonly consumed foodstuffs and are thought to have minimum side effects. This review article describes the detailed mechanisms of oxidative stress-mediated organ pathophysiology and the ultimate fate of the cells either to survive or to undergo necrotic or apoptotic death. The mechanisms underlying the beneficial role of a number of naturally occurring bioactive molecules in oxidative stress-mediated organ pathophysiology have also been included in the review. The review provides useful information about the recent progress in understanding the mechanism(s) of various types of organ pathophysiology, the complex cross-talk between these pathways, as well as their modulation in stressed conditions. Additionally, it suggests possible therapeutic applications of a number of naturally occurring bioactive molecules in conditions involving oxidative stress.
暴露于环境污染物和药物会导致体内的病理生理状况。该领域的研究至关重要，因为关于细胞存活和死亡的知识将有助于设计有效的治疗策略，这些策略是维持身体正常生理功能所必需的。在这方面，天然存在的生物分子可以被认为是潜在的治疗靶点，因为它们通常存在于常见的食物中，并且被认为副作用最小。本文综述详细描述了氧化应激介导的器官病理生理学的机制以及细胞是存活还是发生坏死或凋亡死亡的最终命运。还包括了许多天然生物活性分子在氧化应激介导的器官病理生理学中发挥有益作用的机制。该综述提供了有关理解各种类型器官病理生理学机制、这些途径之间复杂的串扰以及应激条件下它们的调节的最新进展的有用信息。此外，它还提出了在涉及氧化应激的情况下，一些天然生物活性分子的可能的治疗应用。
