Acibucu Fettah, Öztürk Dilan Damla, Kizildag Cisem, Aslan Muhammed Zubeyir, Gulumsek Erdinc, Sumbul Merve Saracoglu, Neselioglu Salim, Erel Ozcan, Sen Suat, Bankir Mehmet, Sumbul Hilmi Erdem
Department of Internal Medicine, Endocrinology Division, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey,
Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey.
Arch Endocrinol Metab. 2022 Apr 28;66(2):191-197. doi: 10.20945/2359-3997000000448. Epub 2022 Mar 22.
Graves' ophthalmopathy (GO) is a vision-threatening finding observed in approximately half of Graves' disease patients. The pathophysiology of GO is unclear, and one of the suspected factors is oxidative stress. In our study, we compared the relationship between proptosis and SH-SS in patients diagnosed with GO.
In this prospective study, 40 recently diagnosed Graves' disease patients with proptosis, 40 recently diagnosed Graves' disease patients without GO and 30 healthy individuals with similar demographic characteristics were included. Serum thiol-disulfide (SH-SS) measurements were performed. Eye examinations were performed by a single ophthalmologist to check for the presence of GO, and proptosis values were recorded with a Hertel exophthalmometer.
Total SH values were lower in the group with proptosis than in the other groups (p < 0.05). Total and native SH values were lower in patients without proptosis than in the control group (p < 0.05). Total SH, native SH and SS levels were independently associated with proptosis (p < 0.05). According to this analysis, it was found that increasing SS and decreasing total and native SH levels increased the probability of proptosis by 24.4%, 32.7% and 32.4%, respectively.
A decrease in SH, which is a natural antioxidant that protects the body against oxidative stress, and an increase in SS are important signs of oxidative damage. Proptosis and SH-SS are closely related in GO. This may help us detect GO and proptosis in Graves' patients. It can also assist in developing new options for preventing and treating GO.
Graves眼病（GO）是约半数Graves病患者中出现的一种威胁视力的表现。GO的病理生理学尚不清楚，氧化应激是可疑因素之一。在我们的研究中，我们比较了GO患者眼球突出与巯基-二硫键（SH-SS）之间的关系。
在这项前瞻性研究中，纳入了40例近期诊断为Graves病且有眼球突出的患者、40例近期诊断为Graves病但无GO的患者以及30例具有相似人口统计学特征的健康个体。进行了血清硫醇-二硫键（SH-SS）测量。由一名眼科医生进行眼部检查以检查是否存在GO，并用Hertel眼球突出计记录眼球突出值。
有眼球突出的组中总SH值低于其他组（p<0.05）。无眼球突出的患者总SH值和天然SH值低于对照组（p<0.05）。总SH、天然SH和二硫键水平与眼球突出独立相关（p<0.05）。根据该分析，发现二硫键增加以及总SH和天然SH水平降低分别使眼球突出的概率增加24.4%、32.7%和32.4%。
作为保护身体免受氧化应激的天然抗氧化剂的SH减少以及二硫键增加是氧化损伤的重要迹象。在GO中，眼球突出与SH-SS密切相关。这可能有助于我们在Graves病患者中检测GO和眼球突出。它还可以协助开发预防和治疗GO的新方法。
