Aghabiklooei Abbas, Shadnia Shahin, Hassanian-Moghaddam Hossein, Zamani Nasim
Arh Hig Rada Toksikol. 2013 Sep;64(3):439-43. doi: 10.2478/10004-1254-64-2013-2347.
Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon. In most of the previously reported cases of MTD-related ARDS, MTD was ingested orally in the form of tablets in high or unknown amounts. Despite the findings from the available literature, this case report is aimed at demonstrating that even small amounts of MTD syrup can cause ARDS earlier than it is usually expected. We present a non-addicted MTD-overdosed patient who developed ARDS after ingesting a very small amount of MTD syrup. We suggest close monitoring of MTD-overdosed patients from at least 48 h to 72 h for possible respiratory complications such as pulmonary oedema.
美沙酮（MTD）毒性所致急性呼吸窘迫综合征（ARDS）是一种已知但相当罕见的现象。在大多数先前报道的与MTD相关的ARDS病例中，MTD是以片剂形式口服摄入，剂量高或不明。尽管现有文献有相关发现，但本病例报告旨在表明，即使少量美沙酮糖浆也可导致比通常预期更早发生的ARDS。我们报告一例非成瘾性美沙酮过量患者，该患者在摄入极少量美沙酮糖浆后发生了ARDS。我们建议对美沙酮过量患者至少密切监测48至72小时，以预防可能出现的呼吸并发症，如肺水肿。
