Garg Bindu, Yadav Nirmal, Vardhan Harsha, De A K
Assistant Professor, Department of Physiology, Shri Ram Murti Smarak Institute of Medical Sciences , Bhojipura, Bareilly- 243202, Uttar Pradesh, India .
J Clin Diagn Res. 2013 Aug;7(8):1599-603. doi: 10.7860/JCDR/2013/6227.3235. Epub 2013 Aug 1.
Echocardiographic determination of Left Ventricle Mass (LVM) - an important marker of cardiovascular disease, has been given a lot of importance in clinical diagnosis and in planning of treatment. Clinically asymptomatic compensated hypertensives show some pathological findings which are indicative of left ventricular dysfunction.
The study population of 106 males, after a detailed clinical examination, were evaluated by echocardiography and were classified as per the body mass index classification of WHO Western Pacific Region in 2000 for Asian population. Fasting blood samples were taken to estimate blood sugar and lipid profile.
It was observed that subjects in normal range of body mass index <45 years (23.68%) and >45 years (16.1%), subjects of overweight <45 years (15.7%) and >45 years (10.29%) and obese I and II<45 years (60.52%) and >45 years (73.52%). The comparison between left ventricular mass which was indexed to height(2.7) in subjects who were <45 years and >45years was observed to be statistically significant (p<0.03). On comparing LVM/ht(2.7) of normal BMI group with that of those with higher BMIs, it was noted to be significantly different (p<0.009), which was suggestive of adverse effects of increasing BMI on LVM. It was also observed that persons with increased BMIs showed changes in left ventricular geometry - 30.13% had concentric hypertrophy, 17.80% had concentric remodeling, 8.21% had eccentric hypertrophy and that 38.35% had normal left ventricle geometry.
The present study therefore, indicated that it was better to do an echocardiographic screening of asymptomatic subjects who had even a marginal increase in blood pressure and BMI, to diagnose potential cardiac dysfunction.
超声心动图测定左心室质量（LVM）——心血管疾病的一个重要标志物，在临床诊断和治疗规划中具有重要意义。临床上无症状的代偿性高血压患者表现出一些提示左心室功能障碍的病理特征。
对106名男性研究对象进行详细的临床检查后，通过超声心动图进行评估，并根据世界卫生组织西太平洋区域2000年针对亚洲人群的体重指数分类进行分类。采集空腹血样以评估血糖和血脂水平。
观察到体重指数在正常范围的45岁以下（23.68%）和45岁以上（16.1%）的研究对象，超重的45岁以下（15.7%）和45岁以上（10.29%）的研究对象，以及I级和II级肥胖的45岁以下（60.52%）和45岁以上（73.52%）的研究对象。观察到45岁以下和45岁以上的研究对象中，以身高（2.7）为指数的左心室质量比较具有统计学意义（p<0.03）。比较正常体重指数组与较高体重指数组的LVM/ht(2.7)，发现存在显著差异（p<0.009），这表明体重指数增加对左心室质量有不良影响。还观察到体重指数增加的人左心室几何形状发生变化——30.13%有向心性肥厚，17.80%有向心性重塑，8.21%有离心性肥厚，38.35%左心室几何形状正常。
因此，本研究表明，对血压和体重指数即使有轻微升高的无症状研究对象进行超声心动图筛查，以诊断潜在的心脏功能障碍，效果更佳。
