Rusthoven J J, Robinson J B, Kolin A, Pinkerton P H
Cancer. 1985 Jul 15;56(2):289-93. doi: 10.1002/1097-0142(19850715)56:2<289::aid-cncr2820560215>3.0.co;2-9.
While using the natural killer (NK) cell-associated HNK-1 antibody in a panel of hematopoietic cell markers, the authors found that metastatic tumor cells in the bone marrow of a patient with disseminated prostatic carcinoma stained strongly with this antibody using an indirect immunofluorescence technique. More than 50% of cells from the patient's prostate also reacted with HNK-1. Subsequent study of frozen sections of prostate tissue from patients with benign prostatic hypertrophy (BPH) showed that HNK-1 reacted with prostatic epithelium and the contents of the glandular lumina. Two other markers associated with NK cells (OKM1 and OKT3) were not detected on nonneoplastic or neoplastic prostatic epithelial cells using a two-color immunofluorescence technique. Recent reports have shown that the HNK-1 antibody also detects an antigen on cells of neuroectodermal origin. The authors have concluded that HNK-1 also reacts with prognostic epithelium in patients with BPH and may be useful as another marker for metastatic carcinoma of the prostate.
在一组造血细胞标志物中使用自然杀伤（NK）细胞相关的HNK-1抗体时，作者发现，采用间接免疫荧光技术，一名播散性前列腺癌患者骨髓中的转移瘤细胞与该抗体发生强烈反应。该患者前列腺中超过50%的细胞也与HNK-1发生反应。随后对良性前列腺增生（BPH）患者前列腺组织冰冻切片的研究表明，HNK-1与前列腺上皮及腺腔内容物发生反应。使用双色免疫荧光技术，在非肿瘤性或肿瘤性前列腺上皮细胞上未检测到另外两种与NK细胞相关的标志物（OKM1和OKT3）。最近的报告显示，HNK-1抗体还能检测神经外胚层来源细胞上的一种抗原。作者得出结论，HNK-1也与BPH患者的预后上皮发生反应，可能可用作前列腺转移癌的另一种标志物。
