Akerlund Elisabeth, Esbjörnsson Eva, Sunnerhagen Katharina S, Björkdahl Ann
Department of Rehabilitation Medicine, Sahlgrenska University Hospital , Gothenburg , Sweden .
Brain Inj. 2013;27(13-14):1649-57. doi: 10.3109/02699052.2013.830195. Epub 2013 Oct 2.
To study if computerized working memory (WM) training, in the sub-acute phase after acquired brain injury, in patients with impaired WM, improves WM, cognition and psychological health.
A randomized study (n = 47) with an intervention group (IG) and a control group (CG), mean age 47.7 years. The WAIS-III NI, Digit span, Arithmetic, Letter-Number Sequences (Working Memory sub-scale), Spatial span, the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) and the self-rating scales DEX and HADS were administered at baseline and at follow-ups at 6 and 18 weeks. Both groups underwent integrated rehabilitation. The IG also trained with the computerized WM training program, Cogmed QM, which was offered to the CG and followed up after the study completion.
Both groups improved after their WM training in Working Memory, BNIS and in Digit span, particularly the reversed section. Both the BNIS and the Digit span differed significantly between the IG and CG due to the greater improvement in the IG after their WM training. Psychological health improved as both groups reported less depressive symptoms and the CG also less anxiety, after the training.
Results indicated that computerized WM training can improve working memory, cognition and psychological health.
研究在获得性脑损伤后的亚急性期，对工作记忆受损的患者进行计算机化工作记忆（WM）训练是否能改善工作记忆、认知和心理健康。
一项随机研究（n = 47），分为干预组（IG）和对照组（CG），平均年龄47.7岁。在基线以及6周和18周随访时，实施韦氏成人智力量表第三版神经心理学成套测验（WAIS-III NI）、数字广度、算术、字母-数字排序（工作记忆分量表）、空间广度、巴罗神经学研究所高级脑功能筛查量表（BNIS）以及自评量表DEX和医院焦虑抑郁量表（HADS）。两组均接受综合康复治疗。干预组还使用计算机化工作记忆训练程序Cogmed QM进行训练，该程序也提供给对照组，并在研究结束后进行随访。
两组在工作记忆训练后，工作记忆、BNIS和数字广度均有所改善，尤其是倒序部分。由于干预组在工作记忆训练后改善更大，BNIS和数字广度在干预组和对照组之间存在显著差异。训练后，两组报告的抑郁症状均减少，对照组的焦虑症状也减少，心理健康状况得到改善。
结果表明，计算机化工作记忆训练可改善工作记忆、认知和心理健康。
