Chernova A A, Nikulina S Iu, Tret'iakova S S, Maksimov V N, Voevoda M I, Chernov V N
Kardiologiia. 2014;54(10):26-31. doi: 10.18565/cardio.2014.10.26-31.
We studied the role of endothelial nitric oxide synthase gene polymorphism 4a/4b in development of such disturbances of cardiac conduction as atrioventricular (AV) block and sick sinus node syndrome (SSNS). We examined 69 subjects (36 men, 33 women) with AV block and 90 subjects (33 men and 57 women) with SSNS. They were divided into groups in dependence on type of conduction disorder and sex. Probands with pathologies studied composed separate groups. All participants underwent included clinical-instrumental cardiological examination and molecular genetic study of eNOS gene polymorphisms. In all groups we revealed significant predominance of a rare homozygous genotype 4b/4b and tendency to decreased number of carriers of widely spread 4a/4a allele.
我们研究了内皮型一氧化氮合酶基因多态性4a/4b在诸如房室传导阻滞和病态窦房结综合征（SSNS）等心脏传导障碍发生发展中的作用。我们检查了69例患有房室传导阻滞的受试者（36名男性，33名女性）和90例患有病态窦房结综合征的受试者（33名男性和57名女性）。他们根据传导障碍类型和性别分组。患有所研究病理的先证者组成单独的组。所有参与者均接受了临床仪器心脏检查和eNOS基因多态性的分子遗传学研究。在所有组中，我们发现罕见的纯合基因型4b/4b显著占优势，并且广泛传播的4a/4a等位基因携带者数量有减少的趋势。
