环孢素A对体外单个核血细胞和单核细胞促凝血活性的影响。
Effect of cyclosporine A on procoagulant activity in mononuclear blood cells and monocytes in vitro.
作者信息
Carlsen E, Mallet A C, Prydz H
出版信息
Clin Exp Immunol. 1985 May;60(2):407-16.
Abstract
Monocytes and macrophages synthesize thromboplastin when induced by a number of compounds. Our experiments show that cyclosporine A (CyA) enhances the synthesis of procoagulant activity in monocytes and in whole mononuclear cells (MNC) about two-fold when phytohaemagglutinin (PHA) is the stimulant. The enhancement is inhibited by actinomycin D and cycloheximide. CyA alone had no effect, but in the presence of PHA or phorbol ester CyA induces or enhances the synthesis of a vitamin K-dependent procoagulant in the MNC cultures. This procoagulant acts synergistically with thromboplastin synthesized in the same cultures.
摘要
单核细胞和巨噬细胞在多种化合物的诱导下会合成凝血活酶。我们的实验表明，当以植物血凝素（PHA）作为刺激物时，环孢素A（CyA）可使单核细胞和全单核细胞（MNC）中的促凝血活性合成增强约两倍。放线菌素D和环己酰亚胺可抑制这种增强作用。单独使用CyA没有效果，但在PHA或佛波酯存在的情况下，CyA可诱导或增强MNC培养物中维生素K依赖性促凝血剂的合成。这种促凝血剂与在相同培养物中合成的凝血活酶协同作用。
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