Sari Dina Permata, Ninomiya Masayuki, Efdi Mai, Santoni Adlis, Ibrahim Sanusi, Tanaka Kaori, Koketsu Mamoru
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Andalas.
J Oleo Sci. 2013;62(10):843-8. doi: 10.5650/jos.62.843.
Polyalthia is a versatile genus of shrubs and trees found in tropic and sub-tropic regions. In this study, three clerodane diterpenes, kolavenic acid (1), polyalthialdoic acid (2), and 16α-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (3) isolated from Polyalthia longifolia leaves were evaluated for their apoptotic potential against human leukemia HL-60 cells. Compounds 2 and 3 inhibited cell proliferation with IC₅₀ values of 21.8 and 13.7 μM, respectively. Morphological changes and DNA fragmentation analysis indicated that these diterpenes induce apoptotic cell death in the HL-60 cells. Our results revealed the importance of P. longifolia as a chemopreventive medicinal plant.
暗罗属是一种在热带和亚热带地区发现的多功能灌木和乔木属。在本研究中，对从长叶暗罗叶中分离出的三种克罗烷二萜类化合物，即可乐韦酸（1）、暗罗醛酸（2）和16α-羟基-克罗达-3,13(14)Z-二烯-15,16-内酯（3），针对人白血病HL-60细胞的凋亡潜力进行了评估。化合物2和3抑制细胞增殖，IC₅₀值分别为21.8和13.7 μM。形态学变化和DNA片段化分析表明，这些二萜类化合物可诱导HL-60细胞发生凋亡性细胞死亡。我们的结果揭示了长叶暗罗作为一种化学预防药用植物的重要性。
