Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
Fitoterapia. 2020 Nov;147:104734. doi: 10.1016/j.fitote.2020.104734. Epub 2020 Sep 29.
Two new C triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC value of 22.43 μM.
从算盘子中分离得到了两个新的 C 型三萜， polysimiaric 酸 A（1）和 B（2），以及一个新的 clerodane 二萜，16,16-二甲氧基-cleroda-3,13Z-二烯-15-酸（3），此外还有六个已知化合物。通过分析 1D 和 2D NMR 数据确定了它们的结构。对三种新化合物进行了对五种人肿瘤细胞系的细胞毒性测试。化合物 3 对 SMMC-7721 具有细胞毒性，IC 值为 22.43 μM。
