Gutierrez Maximiliano Gabriel
Division of Mycobacterial Research; Medical Research Council; National Institute for Medical Research; London, UK.
Small GTPases. 2013 Jul-Sep;4(3):148-58. doi: 10.4161/sgtp.25604. Epub 2013 Jul 30.
Rab GTPases are at the central node of the machinery that regulates trafficking of organelles, including phagosomes. Thanks to the unique combination of high quality phagosome purification with highly sensitive proteomic studies, the network of Rab proteins that are dynamically associated with phagosomes during the process of maturation of this organelle is relatively well known. Whereas the phagosomal functions of many of the Rab proteins associated with phagosomes are characterized, the role(s) of most of these trafficking regulators remains to be identified. In some cases, even when the function in the context of phagosome biology is described, phagosomal Rab proteins seem to have similar roles. This review summarizes the current knowledge about the identity and function of phagosomal Rab GTPases, with a particular emphasis on new evidence that clarify these seemingly overlapping Rab functions during phagosome maturation.
Rab GTP 酶处于调节细胞器（包括吞噬体）运输机制的核心节点。由于高质量的吞噬体纯化技术与高灵敏度蛋白质组学研究的独特结合，在该细胞器成熟过程中与吞噬体动态相关的 Rab 蛋白网络已相对为人所知。虽然许多与吞噬体相关的 Rab 蛋白的吞噬体功能已得到表征，但这些运输调节因子中的大多数的作用仍有待确定。在某些情况下，即使描述了其在吞噬体生物学背景下的功能，吞噬体 Rab 蛋白似乎也具有相似的作用。本综述总结了目前关于吞噬体 Rab GTP 酶的身份和功能的知识，特别强调了有助于阐明吞噬体成熟过程中这些看似重叠的 Rab 功能的新证据。
