Sundar S K, Barile G, Menezes J
Int J Immunopharmacol. 1985;7(2):187-92. doi: 10.1016/0192-0561(85)90025-6.
Isoprinosine, a synthetic purine derivative and a potentially useful immunostimulating agent, was tested for its ability to enhance lymphocyte responses to Epstein-Barr virus (EBV) antigens and to autologous EBV-transformed lymphocytes. Isoprinosine significantly enhanced the response of sensitized lymphocytes (i.e. from EBV-seropositive individuals) to EBV antigens, while it has no effect on the lack of response of unsensitized lymphocytes (i.e. from EBV-seronegative individuals) to these antigens. In addition, isoprinosine enhanced lymphocytes response to autologous EBV-transformed cells, and potentiated the generation of cytotoxic lymphocytes. From these observations, and since immunosuppression is commonly observed in EBV-associated malignancies and other EBV-induced disorders, it may be important to point out that the use of isoprinosine as an immunostimulating agent in patients with these diseases deserves serious consideration.
异丙肌苷是一种合成嘌呤衍生物，也是一种潜在有用的免疫刺激剂，已对其增强淋巴细胞对爱泼斯坦-巴尔病毒（EBV）抗原以及对自体EBV转化淋巴细胞反应的能力进行了测试。异丙肌苷显著增强了致敏淋巴细胞（即来自EBV血清阳性个体）对EBV抗原的反应，而对未致敏淋巴细胞（即来自EBV血清阴性个体）对这些抗原缺乏反应则没有影响。此外，异丙肌苷增强了淋巴细胞对自体EBV转化细胞的反应，并增强了细胞毒性淋巴细胞的生成。基于这些观察结果，并且由于在EBV相关恶性肿瘤和其他EBV诱导的疾病中普遍观察到免疫抑制，可能有必要指出，在患有这些疾病的患者中使用异丙肌苷作为免疫刺激剂值得认真考虑。
