Sundar S K, Menezes J
Int J Immunopharmacol. 1986;8(1):101-6. doi: 10.1016/0192-0561(86)90078-0.
Acute infectious mononucleosis (IM) is accompanied by measurable abnormalities of immune function, including a transient immunosuppression. The sera of patients with acute IM contain an IgG blocking factor which binds to T-lymphocytes and decreases their responses to antigens and mitogens. The experiments reported herein indicate that isoprinosine, an immunopotentiating agent, can reverse this inhibition of T cells by IM-associated IgG blocking factor. Isoprinosine may be a useful tool in understanding the interactions between blocking factors and lymphocytes; moreover, isoprinosine may be of value in patients with abnormal clinical responses to Epstein-Barr virus (EBV) such as chronic IM or persistent active EBV infections.
急性传染性单核细胞增多症（IM）伴有可测量的免疫功能异常，包括短暂的免疫抑制。急性IM患者的血清中含有一种IgG阻断因子，该因子与T淋巴细胞结合并降低其对抗抗原和有丝分裂原的反应。本文报道的实验表明，免疫增强剂异丙肌苷可以逆转IM相关IgG阻断因子对T细胞的这种抑制作用。异丙肌苷可能是理解阻断因子与淋巴细胞之间相互作用的有用工具；此外，异丙肌苷对于对爱泼斯坦-巴尔病毒（EBV）有异常临床反应的患者，如慢性IM或持续性活动性EBV感染，可能具有价值。
