利用认知神经科学开发改善精神分裂症认知的新疗法：CNTRICS 为动物模型选择了认知范式。
Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models.
机构信息
Department of Psychiatry, Columbia University, New York, NY, USA; Department of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA.
出版信息
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2087-91. doi: 10.1016/j.neubiorev.2013.09.011. Epub 2013 Sep 30.
Abstract
Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes.
摘要
在过去的二十年中，人们对精神分裂症认知障碍的致残性和治疗抵抗性的认识有了显著提高。为了应对精神分裂症治疗中这一尚未满足的需求，开展了“认知神经科学治疗改善精神分裂症认知（CNTRICS）”研究计划。CNTRICS 的目标是利用认知神经科学，开发一套基于大脑的工具来测量精神分裂症患者的认知，并测试新的治疗方法。CNTRICS 会议专注于开发具有认知结构有效性的任务，用于人类和动物模型研究。本期特刊介绍了 CNTRICS 为动物模型系统选择的认知测试范式。这些范式旨在测量感知、注意力、执行功能、工作记忆、物体/关系长期记忆和社会/情感过程等领域的认知结构。
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