通过局部内质网运输增加迁移细胞中的钙。
WRAMPing up calcium in migrating cells by localized ER transport.
机构信息
Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA; Microbiology Doctoral Training Program, Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
出版信息
Dev Cell. 2013 Sep 30;26(6):560-1. doi: 10.1016/j.devcel.2013.09.013.
Abstract
Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rear detachment, and motility.
摘要
形态可塑性和前后极性对于定向细胞迁移至关重要。在本期《发育细胞》中，Witze 等人（2013）证明 Wnt5a 介导的信号转导诱导黑色素瘤细胞皮质内质网定位于尾部，并介导钙流、后部脱离和运动。
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本文引用的文献
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