• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雀鳝嗅神经无髓鞘纤维中钾离子在电活动期间的移动以及恢复过程的动力学。

The movement of potassium ions during electrical activity, and the kinetics of the recovery process, in the non-myelinated fibres of the garfish olfactory nerve.

作者信息

Ritchie J M, Straub R W

出版信息

J Physiol. 1975 Jul;249(2):327-48. doi: 10.1113/jphysiol.1975.sp011018.

DOI:10.1113/jphysiol.1975.sp011018
PMID:240927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1309577/
Abstract
  1. An electrophysiological study was made with the sucrose gap of the compound action potential of the non-myelinated fibres of the garfish olfactory nerve at temperatures between 8 and 22 degrees C. The efflux of 42K with stimulation, and the post-tetanic hyperpolarization following a period of repetitive stimulation, were also studied. 2. At 22 degrees C the compound action potential (at zero conduction distance) reached its peak in about 5 msec and lasted about 12 msec; the conduction velocity was 19.4 cm/sec. The corresponding extrapolated values at 0 degrees C were: time to peak, 16 msec; duration, 37 msec; conduction velocity, 4.2 cm/sec. 3. The rate constant for resting potassium efflux (kr) was 0.0108 min-1 at 22 degrees C and 0.00489 min-1 at 0 degrees C. 4. The extra fractional loss of potassium with stimulation (ks) was 2.02 x 10(-4) impulse-1 at 22 degrees C and 4.41 x 10(-4) impulse-1 at 0 degrees C. 5. Raising the external potassium concentration, or addition of ouabain (1 mM), raised the resting rate of efflux of potassium. 6. The post-tetanic hyperpolarization, which reflects the electrogenic extrusion of sodium ions, indicated a rate constant for active sodium efflux at 22 degrees C of 0.47 min=1. 7. The rate constant was decreased by a 10 degrees C fall in temperature by a factor of 1.73. 8. Increasing the external potassium concentration increased the rate constant, apparently by potassium combining with some site with an equilibrium dissociation constant of 1.2 mMM. 9. The rate constant was decreased slightly in acidic solutions and increased slightly in alkaline solutions. 10. 14C-labelled ouabain was found to bind to the garfish olfactory nerve with an equilibrium dissociation constant of about 0.5 muM. The maximum saturable binding capacity, 22.3 p-mole/mg dry, suggests that there are about 350 sodium pumping sites per square micron membrane.
摘要
  1. 在8至22摄氏度的温度范围内，利用蔗糖间隙法对海鳗嗅神经无髓鞘纤维的复合动作电位进行了电生理研究。还研究了刺激时42K的外流以及重复刺激一段时间后的强直后超极化。2. 在22摄氏度时，复合动作电位（在零传导距离处）在约5毫秒内达到峰值，持续约12毫秒；传导速度为19.4厘米/秒。在0摄氏度时相应的外推值为：达到峰值的时间为16毫秒；持续时间为37毫秒；传导速度为4.2厘米/秒。3. 静息钾外流的速率常数（kr）在22摄氏度时为0.0108分钟-1，在0摄氏度时为0.00489分钟-1。4. 刺激时钾的额外分数损失（ks）在22摄氏度时为2.02×10（-4）脉冲-1，在0摄氏度时为4.41×10（-4）脉冲-1。5. 提高细胞外钾浓度或添加哇巴因（1毫摩尔）可提高钾的静息外流速率。6. 反映钠离子电源性外流的强直后超极化表明，在22摄氏度时活性钠外流的速率常数为0.47分钟=1。7. 温度下降10摄氏度，速率常数降低1.73倍。8. 增加细胞外钾浓度会增加速率常数，显然是因为钾与某个位点结合，其平衡解离常数为1.2毫摩尔。9. 在酸性溶液中速率常数略有降低，在碱性溶液中略有增加。10. 发现14C标记的哇巴因与海鳗嗅神经结合，平衡解离常数约为0.5微摩尔。最大饱和结合容量为22.3皮摩尔/毫克干重，表明每平方微米膜约有350个钠泵位点。

相似文献

1
The movement of potassium ions during electrical activity, and the kinetics of the recovery process, in the non-myelinated fibres of the garfish olfactory nerve.雀鳝嗅神经无髓鞘纤维中钾离子在电活动期间的移动以及恢复过程的动力学。
J Physiol. 1975 Jul;249(2):327-48. doi: 10.1113/jphysiol.1975.sp011018.
2
On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations.关于哺乳动物无髓神经纤维中的生电钠泵及其被各种外部阳离子激活的情况。
J Physiol. 1968 May;196(1):183-221. doi: 10.1113/jphysiol.1968.sp008502.
3
Post-tetanic hyperpolarization, sodium-potassium-activated adenosine triphosphatase and high energy phosphate levels in garfish olfactory nerve.雀鳝嗅神经中的强直后超极化、钠钾激活三磷酸腺苷酶及高能磷酸水平
J Physiol. 1976 Mar;256(1):41-60. doi: 10.1113/jphysiol.1976.sp011310.
4
Increase in efflux of inorganic phosphate during electrical activity in small non-myelinated nerve fibres.小的无髓神经纤维电活动期间无机磷酸盐外流增加。
J Physiol. 1978 Jan;274:539-48. doi: 10.1113/jphysiol.1978.sp012165.
5
Phosphate efflux and oxygen consumption in small non-myelinated nerve fibres at rest and during activity.静息和活动状态下小的无髓神经纤维中的磷酸盐外流和氧消耗。
J Physiol. 1979 Feb;287:315-27. doi: 10.1113/jphysiol.1979.sp012661.
6
Action potential fatigue in nonmyelinated nerve fibers: garfish olfactory and rabbit vagus nerve.无髓神经纤维中的动作电位疲劳：雀鳝嗅觉神经和兔迷走神经
Can J Physiol Pharmacol. 1976 Aug;54(4):485-93. doi: 10.1139/y76-068.
7
Movements of labelled sodium ions in isolated rat superior cervical ganglia.标记钠离子在离体大鼠颈上神经节中的运动。
J Physiol. 1974 Oct;242(2):321-51. doi: 10.1113/jphysiol.1974.sp010710.
8
The recovery heat production in non-myelinated garfish olfactory nerve fibres.无髓海鳗嗅觉神经纤维中的恢复产热
J Physiol. 1979 Jul;292:167-75. doi: 10.1113/jphysiol.1979.sp012844.
9
The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricle.蛙心室心动周期中钾、钠、氯、钙、硫酸根离子以及山梨醇和甘油的外流情况。
J Physiol. 1968 Mar;195(2):283-315. doi: 10.1113/jphysiol.1968.sp008459.
10
Uptake of potassium by nonmyelinating Schwann cells induced by axonal activity.轴突活动诱导无髓鞘施万细胞摄取钾离子。
J Neurophysiol. 1994 Dec;72(6):2570-9. doi: 10.1152/jn.1994.72.6.2570.

引用本文的文献

1
An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia.星形胶质细胞在血管性认知障碍和痴呆中的新作用。
J Neurochem. 2018 Mar;144(5):644-650. doi: 10.1111/jnc.14273. Epub 2018 Jan 22.
2
Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice.转基因小鼠中的免疫疗法、血管病理学和微出血
CNS Neurol Disord Drug Targets. 2009 Mar;8(1):50-64. doi: 10.2174/187152709787601858.
3
Uptake of adenosine and release of adenine derivatives in mammalian non-myelinated nerve fibres at rest and during activity.哺乳动物无髓神经纤维在静息和活动时腺苷的摄取及腺嘌呤衍生物的释放。
J Physiol. 1982 Feb;323:589-602. doi: 10.1113/jphysiol.1982.sp014093.
4
Rapid mechanical and thermal changes in the garfish olfactory nerve associated with a propagated impulse.针鱼嗅觉神经中与传播冲动相关的快速机械和热变化。
Biophys J. 1989 Jun;55(6):1033-40. doi: 10.1016/S0006-3495(89)82902-9.
5
The heat production associated with the passage of a single impulse in pike olfactory nerve fibres.与梭子鱼嗅觉神经纤维中单个冲动传导相关的产热。
J Physiol. 1975 Jul;249(2):349-68. doi: 10.1113/jphysiol.1975.sp011019.
6
The optical spike. Structure of the olfactory nerve of pike and rapid birefringence changes during excitation.光学峰。梭子鱼嗅神经的结构以及兴奋过程中的快速双折射变化。
Pflugers Arch. 1976 Nov 30;367(1):67-76. doi: 10.1007/BF00583658.
7
A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.一种标记石房蛤毒素及其与兔迷走神经、龙虾步足和雀鳝嗅神经无髓纤维结合的新方法。
J Physiol. 1976 Oct;261(2):477-94. doi: 10.1113/jphysiol.1976.sp011569.
8
Increase in efflux of inorganic phosphate during electrical activity in small non-myelinated nerve fibres.小的无髓神经纤维电活动期间无机磷酸盐外流增加。
J Physiol. 1978 Jan;274:539-48. doi: 10.1113/jphysiol.1978.sp012165.
9
Activity-dependent changes in conduction velocity in the olfactory nerve of the tortoise.乌龟嗅神经中传导速度的活动依赖性变化。
Pflugers Arch. 1979 Sep;381(3):209-16. doi: 10.1007/BF00583251.
10
The recovery heat production in non-myelinated garfish olfactory nerve fibres.无髓海鳗嗅觉神经纤维中的恢复产热
J Physiol. 1979 Jul;292:167-75. doi: 10.1113/jphysiol.1979.sp012844.

本文引用的文献

1
THE INITIAL HEAT PRODUCTION ASSOCIATED WITH THE NERVE IMPULSE IN CRUSTACEAN AND MAMMALIAN NON-MYELINATED NERVE FIBRES.甲壳类动物和哺乳动物无髓神经纤维中与神经冲动相关的初始产热
J Physiol. 1965 May;178(2):368-83. doi: 10.1113/jphysiol.1965.sp007633.
2
Effect of frequency of electrical stimulation on the concentration of intermediary metabolites in mammalian non-myelinated fibres.电刺激频率对哺乳动物无髓鞘纤维中中间代谢产物浓度的影响。
J Physiol. 1959 Oct;148(2):353-61. doi: 10.1113/jphysiol.1959.sp006292.
3
The action of acetylcholine on conduction in mammalian non-myelinated fibres and its prevention by an anticholinesterase.乙酰胆碱对哺乳动物无髓鞘纤维传导的作用及其被抗胆碱酯酶的抑制作用。
J Physiol. 1960 Jun;152(1):141-58. doi: 10.1113/jphysiol.1960.sp006476.
4
On excitation of non-medullated afferent fibres in the vagus and aortic nerves by pharmacological agents.关于通过药理学试剂刺激迷走神经和主动脉神经中的无髓传入纤维。
J Physiol. 1957 Aug 29;138(1):31-43. doi: 10.1113/jphysiol.1957.sp005836.
5
The hyperpolarization which follows activity in mammalian non-medullated fibres.哺乳动物无髓鞘纤维活动后出现的超极化。
J Physiol. 1957 Apr 3;136(1):80-97. doi: 10.1113/jphysiol.1957.sp005744.
6
Olfactory nerve fibers.嗅神经纤维。
J Gen Physiol. 1956 Mar 20;39(4):473-96. doi: 10.1085/jgp.39.4.473.
7
The oxygen consumption of mammalian non-myelinated nerve fibres at rest and during activity.哺乳动物无髓神经纤维在静息和活动时的氧消耗。
J Physiol. 1967 Feb;188(3):309-29. doi: 10.1113/jphysiol.1967.sp008141.
8
The movements of labelled ions in mammalian non-myelinated nerve fibres.标记离子在哺乳动物无髓神经纤维中的运动。
J Physiol. 1965 Jul;179(2):333-67. doi: 10.1113/jphysiol.1965.sp007666.
9
A comparison of the effect of temperature, metabolic inhibitors and of ouabain on the electrogenic componen of the sodium pump in mammalian non-myelinated nerve fibres.温度、代谢抑制剂及哇巴因对哺乳动物无髓神经纤维钠泵电生成成分作用的比较
J Physiol. 1969 Oct;204(3):523-38. doi: 10.1113/jphysiol.1969.sp008929.
10
Effect of electrical activity on the concentration of phosphorylated metabolites and inorganic phosphate in mammalian non-myelinated nerve fibres.电活动对哺乳动物无髓神经纤维中磷酸化代谢物和无机磷酸盐浓度的影响。
J Physiol. 1969 Jun;202(2):90P-92P.