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药物初治注意缺陷多动障碍女孩持续存在原始反射。

Persisting primitive reflexes in medication-naïve girls with attention-deficit and hyperactivity disorder.

机构信息

Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech republic.

出版信息

Neuropsychiatr Dis Treat. 2013;9:1457-61. doi: 10.2147/NDT.S49343. Epub 2013 Sep 20.

DOI:10.2147/NDT.S49343
PMID:24092983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3788695/
Abstract

BACKGROUND AND OBJECTIVES

Recent and historical findings suggest that later-developed functions during brain ontogenesis related to higher levels of cognitive and motor integration tend to replace the older, more primitive, ones, and the persistence of the older functions may be linked to specific neuropsychiatric disorders. Currently, there is growing evidence to suggest that persisting primitive reflexes may be related to developmental and neurodegenerative disorders. Preliminary data also suggest that persisting primitive reflexes may be specifically linked to attention-deficit and hyperactivity disorder (ADHD).

METHODS

In the study reported here, we tested to what extent the persisting primitive asymmetric tonic neck reflex and symmetric tonic neck reflex are related to ADHD symptoms measured by Conners' Parent Questionnaire in 35 medication-naïve girls of school age (8-11 years) with ADHD. The results were compared with those of a control group of 30 girls of the same age.

RESULTS

This study showed that persisting primitive reflexes are closely linked to ADHD symptoms.

CONCLUSION

The data suggest that ADHD symptoms may be linked to more primitive neural mechanisms interfering with higher brain functions due to insufficiently developed cognitive and motor integration.

摘要

背景与目的

最近和历史上的发现表明,大脑发生过程中与更高水平的认知和运动整合相关的后期发育功能往往会取代那些更原始、更早期的功能,而较早期功能的持续存在可能与特定的神经精神障碍有关。目前,越来越多的证据表明,持续存在的原始反射可能与发育和神经退行性疾病有关。初步数据还表明,持续存在的原始反射可能与注意力缺陷多动障碍(ADHD)有特定联系。

方法

在本研究中,我们测试了在 35 名未经药物治疗的学龄期(8-11 岁)ADHD 女孩中,持续存在的不对称紧张性颈反射和对称性紧张性颈反射与 Conners 父母问卷测量的 ADHD 症状之间的关系。将结果与 30 名同龄的对照组女孩进行比较。

结果

本研究表明,持续存在的原始反射与 ADHD 症状密切相关。

结论

数据表明,ADHD 症状可能与更原始的神经机制有关,这些机制由于认知和运动整合发育不足而干扰了更高层次的大脑功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef3/3788695/60c4bdd7daa9/ndt-9-1457Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef3/3788695/60c4bdd7daa9/ndt-9-1457Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ef3/3788695/60c4bdd7daa9/ndt-9-1457Fig1.jpg

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