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注意缺陷多动障碍中原始反射的去抑制:对男孩和女孩特定机制的洞察

Disinhibition of Primitive Reflexes in Attention Deficit and Hyperactivity Disorder: Insight Into Specific Mechanisms in Girls and Boys.

作者信息

Bob Petr, Konicarova Jana, Raboch Jiri

机构信息

Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, First Faculty of Medicine and Department of Psychiatry, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia.

Stroder Therapy Center, Cham, Germany.

出版信息

Front Psychiatry. 2021 Nov 8;12:430685. doi: 10.3389/fpsyt.2021.430685. eCollection 2021.

DOI:10.3389/fpsyt.2021.430685
PMID:34819879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8606578/
Abstract

Cognitive and motor disintegration and other functional disturbances in various neuropsychiatric disorders may be related to inhibitory deficits that may manifest as a persistence or re-expression of primitive reflexes and few recent data suggest that these deficits may occur in Attention Deficit and Hyperactivity Disorder (ADHD). We have tested a hypothesis to which extent ADHD symptoms and balance deficits are related to persisting primitive reflexes, such as Asymmetric Tonic Neck Reflex (ATNR) and Symmetric Tonic Neck Reflex (STNR) in 80 medication-naïve children with ADHD (40 boys and 40 girls) in the school age (8-11 years) and compared these data with a control group of 60 children (30 boys and 30 girls). These data show new finding that ADHD symptoms and balance deficits are strongly and specifically associated with persistent ATNR in girls and STNR in boys. These results provide first evidence in medical literature that ADHD in girls and boys is specifically related to distinguished neurological developmental mechanisms related to disinhibition of primitive reflexes.

摘要

各种神经精神疾病中的认知和运动功能瓦解以及其他功能障碍可能与抑制缺陷有关,这些缺陷可能表现为原始反射的持续存在或再次出现,而且最近的数据表明,这些缺陷可能出现在注意力缺陷多动障碍(ADHD)中。我们检验了一个假设,即在80名未服用药物的学龄期(8至11岁)ADHD儿童(40名男孩和40名女孩)中,ADHD症状和平衡缺陷在多大程度上与持续存在的原始反射有关,如非对称性紧张性颈反射(ATNR)和对称性紧张性颈反射(STNR),并将这些数据与60名儿童(30名男孩和30名女孩)的对照组进行了比较。这些数据显示了新的发现,即ADHD症状和平衡缺陷与女孩中持续存在的ATNR以及男孩中持续存在的STNR密切且特定相关。这些结果在医学文献中首次提供了证据,表明男孩和女孩的ADHD分别与原始反射抑制解除相关的不同神经发育机制密切相关。

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本文引用的文献

1
Asymmetric tonic neck reflex and symptoms of attention deficit and hyperactivity disorder in children.儿童的非对称性紧张性颈反射与注意缺陷多动障碍的症状。
Int J Neurosci. 2013 Nov;123(11):766-9. doi: 10.3109/00207454.2013.801471. Epub 2013 Jun 5.
2
Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects.注意缺陷多动障碍抑制和注意的功能磁共振成像研究的荟萃分析:探索任务特异性、兴奋剂药物和年龄效应。
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Predictors of postural stability in children with ADHD.ADHD 儿童姿势稳定性的预测因素。
J Atten Disord. 2011 Oct;15(7):604-10. doi: 10.1177/1087054710370936. Epub 2010 Sep 13.