丝状病毒的复制与转录。
Filovirus replication and transcription.
作者信息
Mühlberger Elke
机构信息
Philipps University of Marburg, Institute of Virology, Hans-Meerwein-Street 2, 35043 Marburg, Germany Tel.: +49 6421 2864 525; ;
出版信息
Future Virol. 2007 Mar;2(2):205-215. doi: 10.2217/17460794.2.2.205.
The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented negative-sense RNA viruses of the order Mononegavirales. The mode of replication and transcription is similar for these viruses. On one hand, the negative-sense RNA genome serves as a template for replication, to generate progeny genomes, and, on the other hand, for transcription, to produce mRNAs. Despite the similarities in the replication/transcription strategy, filoviruses have evolved structural and functional properties that are unique among the nonsegmented negative-sense RNA viruses. Moreover, there are also striking differences in the replication and transcription mechanisms of Marburg and Ebola virus. This includes nucleocapsid formation, the structure of the genomic replication promoter, the protein requirement for transcription and the use of mRNA editing. In this article, the current knowledge of the replication and transcription strategy of Marburg and Ebola virus is reviewed, with focus on the observed differences.
高致病性丝状病毒，如马尔堡病毒和埃博拉病毒，属于单股负链RNA病毒目下的非节段性负链RNA病毒。这些病毒的复制和转录模式相似。一方面，负链RNA基因组作为复制模板，产生子代基因组；另一方面，作为转录模板，产生信使核糖核酸（mRNA）。尽管丝状病毒在复制/转录策略上存在相似性，但它们已经进化出了在非节段性负链RNA病毒中独一无二的结构和功能特性。此外，马尔堡病毒和埃博拉病毒在复制和转录机制上也存在显著差异。这包括核衣壳的形成、基因组复制启动子的结构、转录所需的蛋白质以及mRNA编辑的使用。在本文中，我们综述了马尔堡病毒和埃博拉病毒复制和转录策略的现有知识，重点关注观察到的差异。
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