Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza (BCM390), Houston, TX 77030, USA.
Crit Care Clin. 2013 Oct;29(4):795-806. doi: 10.1016/j.ccc.2013.06.001. Epub 2013 Jul 25.
Necrotizing soft tissue infections (NSTIs) are infrequent yet highly lethal infections, and a high index of suspicion is required for early diagnosis. Diagnosing NSTIs early can be challenging, and knowledge of the available tools is essential to provide appropriate treatment. The mainstay of treatment is early and complete surgical debridement combined with antimicrobial therapy, close monitoring with further debridement as needed, and physiologic support. Mortality continues to be high, and delayed surgical treatment is the most important risk factor. For the long-term recovery of patients with NSTI, providing early physiologic and nutritional support and physical rehabilitation is essential.
坏死性软组织感染（NSTIs）虽不常见，但具有高度致命性，因此需要高度怀疑才能早期诊断。早期诊断 NSTIs 具有一定挑战性，了解现有工具至关重要，这有助于提供适当的治疗。治疗的主要方法是早期和彻底的外科清创术，联合抗菌治疗，密切监测，必要时进一步清创术，以及生理支持。死亡率仍然很高，延迟手术治疗是最重要的危险因素。对于 NSTI 患者的长期康复，提供早期生理和营养支持以及身体康复至关重要。
