Miazza B M, Turberg Y, Guillaume P, Hahne W, Chayvialle J A, Loizeau E
Scand J Gastroenterol Suppl. 1985;112:75-83. doi: 10.3109/00365528509092216.
Pancreatico-biliary diversion (PBD) stimulates pancreatic growth in the rat. The present experiment was designed to investigate the mechanism of this phenomenon. The potential roles of endogenous CCK, gastrin, and secretin were studied. Hormone measurements by specific RIA's show that PBD was associated with higher CCK plasma concentrations and, conversely, with lower gastrin circulating levels. Secretin and pancreatic polypeptide were unaffected by PBD. Seven days' subcutaneous administration of proglumide (1000 mg/kg/day), benzotript (100 mg/kg/day), two CCK and gastrin receptor antagonists, and Ranitidine (100 mg/kg/day) resulted in a significant inhibition of PBD-induced pancreatic growth, assessed by measurements of pancreatic weight, DNA, RNA and protein content. These results suggest, therefore, that CCK plays a central role in the development of the pancreatic adaptive response to PBD.
胰胆分流术（PBD）可刺激大鼠胰腺生长。本实验旨在研究这一现象的机制。研究了内源性胆囊收缩素（CCK）、胃泌素和促胰液素的潜在作用。通过特异性放射免疫分析法（RIA）进行的激素测量显示，PBD与较高的血浆CCK浓度相关，相反，与较低的循环胃泌素水平相关。促胰液素和胰多肽不受PBD影响。连续7天皮下注射丙谷胺（1000毫克/千克/天）、苯曲磷（100毫克/千克/天）这两种CCK和胃泌素受体拮抗剂以及雷尼替丁（100毫克/千克/天），通过测量胰腺重量、DNA、RNA和蛋白质含量评估，结果显示对PBD诱导的胰腺生长有显著抑制作用。因此，这些结果表明，CCK在胰腺对PBD适应性反应的发展中起核心作用。
