Pi Ying, Liao Xianyong, Song Xiaodan, Cao Yuyu, Tang Xiaona, Lin Guobing, Zhong Yanghong
Shenzhen Bao'an District Traditional Chinese Medicine Hospital, Shenzhen, China.
Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
Front Nutr. 2024 Aug 13;11:1396470. doi: 10.3389/fnut.2024.1396470. eCollection 2024.
Chronic kidney disease (CKD) is currently a widespread chronic illness, and its development is influenced by nutrients. Selenium plays a crucial role in the intervention and therapy of various chronic illness. In this study, we aimed to investigate the connection between dietary selenium intake and CKD in adults in the United States.
We included 6,390 individuals from the datasets of the National Health and Nutrition Examination Survey (NHANES) between 2015 and 2018. We used multiple logistic regression, restricted cubic spline regression, and forest plots to investigate the connection between dietary selenium intake and CKD.
After fully adjusting the data of 6,390 individuals from NHANES between 2015 and 2018, 1,523 (23.83%) of the individuals were identified as having chronic kidney disease (CKD). The rates of CKD in participants with average selenium intakes of ≤0.072, 0.072-0.103, 0.103-0.144, and > 0.144 mg/day were 27.53, 25.11, 22.42, and 19.96%, respectively. After adjusting for potential confounding factors, the fully adjusted odds ratio (OR) values for CKD according to dietary selenium intake were 1 (reference), 0.94 (95% confidence interval (CI): 0.79-1.12, = 0.466), 0.82 (95% CI:0.68-0.98, = 0.033), and 0.77 (95% CI:0.63-0.95, = 0.016) for the four selenium intake levels, respectively, with P trend = 0.007. The dietary selenium intake was negatively associated with the incidence of CKD, after adjusting for other confounding factors. The risk of CKD decreased by 7.7% for every additional 0.1 mg of dietary selenium intake.
A higher dietary selenium intake correlates significantly and negatively with the incidence of CKD.
慢性肾脏病（CKD）是目前一种广泛存在的慢性疾病，其发展受营养物质影响。硒在多种慢性疾病的干预和治疗中起关键作用。在本研究中，我们旨在调查美国成年人饮食中硒摄入量与CKD之间的关联。
我们纳入了2015年至2018年国家健康与营养检查调查（NHANES）数据集中的6390名个体。我们使用多元逻辑回归、受限立方样条回归和森林图来研究饮食中硒摄入量与CKD之间的关联。
在对2015年至2018年NHANES的6390名个体的数据进行充分调整后，1523名（23.83%）个体被确定患有慢性肾脏病（CKD）。平均硒摄入量≤0.072、0.072 - 0.103、0.103 - 0.144和>0.144mg/天的参与者中CKD的发生率分别为27.53%、25.11%、22.42%和19.96%。在调整潜在混杂因素后，根据饮食中硒摄入量，CKD的完全调整优势比（OR）值在四个硒摄入水平下分别为1（参考值）、0.94（95%置信区间（CI）：0.79 - 1.12，P = 0.466）、0.82（95%CI：0.68 - 0.98，P = 0.033）和0.77（95%CI：0.63 - 0.95，P = 0.016），P趋势 = 0.007。在调整其他混杂因素后，饮食中硒摄入量与CKD的发生率呈负相关。饮食中硒摄入量每增加0.1mg，CKD的风险降低7.7%。
较高的饮食中硒摄入量与CKD的发生率显著负相关。
