Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China.
Department of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, China.
Nutrients. 2022 Oct 23;14(21):4458. doi: 10.3390/nu14214458.
Previous observational studies have shown that there is a controversial association between selenium levels and chronic kidney disease (CKD). Our aim was to assess the causal relationship between selenium levels and CKD using Mendelian randomization (MR) analysis.
We used the two-sample Mendelian randomization (MR) method to analyze the causal role of selenium levels on CKD risk. The variants associated with selenium levels were extracted from a large genome-wide association study (GWAS) meta-analysis of circulating selenium levels ( = 5477) and toenail selenium levels ( = 4162) in the European population. Outcome data were from the largest GWAS meta-analysis of European-ancestry participants for kidney function to date. Inverse variance weighted (IVW) method was used as the main analysis and a series of sensitivity analyses were carried out to detect potential violations of MR assumptions.
The MR analysis results indicate that the genetically predicted selenium levels were associated with decreased estimated glomerular filtration (eGFR) (effect = -0.0042, 95% confidence interval [CI]: -0.0053-0.0031, = 2.186 × 10) and increased blood urea nitrogen (BUN) (effect = 0.0029, 95% confidence interval [CI]: 0.0006-0.0052, = 0.0136) with no pleiotropy detected.
The MR study indicated that an increased level of selenium is a causative factor for kidney function impairment.
先前的观察性研究表明，硒水平与慢性肾脏病（CKD）之间存在争议性关联。我们的目的是使用孟德尔随机化（MR）分析来评估硒水平与 CKD 之间的因果关系。
我们使用两样本孟德尔随机化（MR）方法来分析硒水平对 CKD 风险的因果作用。与硒水平相关的变异从欧洲人群循环硒水平（n = 5477）和指甲硒水平（n = 4162）的全基因组关联研究（GWAS）荟萃分析中提取。结果数据来自迄今为止欧洲血统参与者肾功能最大的 GWAS 荟萃分析。反方差加权（IVW）方法作为主要分析，进行了一系列敏感性分析以检测潜在的 MR 假设违反。
MR 分析结果表明，遗传预测的硒水平与估算肾小球滤过率（eGFR）降低（效应=-0.0042，95%置信区间[CI]：-0.0053-0.0031， = 2.186 × 10）和血尿素氮（BUN）升高（效应=0.0029，95%置信区间[CI]：0.0006-0.0052， = 0.0136）相关，但未检测到多效性。
MR 研究表明，硒水平升高是肾功能损害的一个致病因素。
