SRM Research Institute, SRM University, Kattankulathur, Chennai 603 203, Tamil Nadu, India; Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
Int J Pharm. 2013 Nov 30;457(1):206-13. doi: 10.1016/j.ijpharm.2013.09.036. Epub 2013 Oct 3.
We report a simple method to fabricate multifunctional polyelectrolyte thin films to load and deliver the therapeutic drugs. The multilayer thin films were assembled by the electrostatic adsorption of poly (allylamine hydrochloride) (PAH) and dextran sulfate (DS). The silver nanoparticles (Ag NPs) biosynthesized from novel Hybanthus enneaspermus leaf extract as the reducing agent were successfully incorporated into the film. The biosynthesized Ag NPs showed excellent antimicrobial activity against the range of enteropathogens, which could be significantly enhanced when used with commercial antibiotics. The assembled silver nano composite multilayer films showed rupture and deformation when they are exposed to laser. The Ag NPs act as an energy absorption center, locally heat up the film and rupture it under laser treatment. The antibacterial drug, moxifloxacin hydrochloride (MH) was successfully loaded into the multilayer films. The total amount of MH release observed was about 63% which increased to 85% when subjected to laser light exposure. Thus, the polyelectrolyte thin film reported in our study has significant potential in the field of remote activated drug delivery, antibacterial coatings and wound dressings.
我们报告了一种简单的方法来制备多功能聚电解质薄膜，以负载和输送治疗药物。多层薄膜通过聚烯丙基盐酸盐（PAH）和硫酸葡聚糖（DS）的静电吸附组装而成。从新型 Hybanthus enneaspermus 叶提取物中生物合成的银纳米粒子（Ag NPs）作为还原剂成功地掺入到薄膜中。生物合成的 Ag NPs 对一系列肠道病原体表现出优异的抗菌活性，与商业抗生素联合使用时，抗菌活性可显著增强。组装的银纳米复合多层薄膜在暴露于激光时会发生破裂和变形。Ag NPs 作为能量吸收中心，在激光处理下局部加热薄膜并使其破裂。抗菌药物盐酸莫西沙星（MH）成功地负载到多层薄膜中。观察到的 MH 总释放量约为 63%，而在激光照射下增加到 85%。因此，我们在研究中报道的聚电解质薄膜在远程激活药物输送、抗菌涂层和伤口敷料领域具有重要的应用潜力。
