Kim Ki Hyun, Moon Sae Rom, Kim Chung Sub, Woo Kyeong Wan, Choi Sang Un, Lee Kang Ro
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
Biosci Biotechnol Biochem. 2013;77(10):2144-7. doi: 10.1271/bbb.130445. Epub 2013 Oct 7.
The new lignan glucoside, acutumoside (1), was isolated from Sinomenium acutum rhizomes together with nine known compounds (2-10). The structure of 1 was elucidated on the basis of extensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance and chemical reactions. Compounds 2, 7, 8, and 10 displayed potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines, while compound 1 showed weak activity against these human tumor cells.
从青风藤根茎中分离得到新的木脂素苷——青风藤苷（1），以及9个已知化合物（2 - 10）。通过广泛的光谱分析，包括二维核磁共振和化学反应，阐明了1的结构。化合物2、7、8和10对A549、SK - OV - 3、SK - MEL - 2和HCT - 15细胞系显示出潜在的抗增殖活性，而化合物1对这些人类肿瘤细胞显示出较弱的活性。
