Shu Jicheng, Liang Fang, Liang Jian, Liang Yonghong, Li Fengqin, Shao Feng, Liu Ronghua, Huang Huilian
Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
Fitoterapia. 2015 Jul;104:64-8. doi: 10.1016/j.fitote.2015.05.010. Epub 2015 May 16.
A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5, 3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan-4-O-β-d-glucopyranoside (3), together with a new natural product (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-1, 2, 3-propanetriol (4) and four known compounds (5-8) were isolated from the rhizomes of Smilax trinervula. Their structures were established mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1-8 were tested in vitro for their cytotoxic activities against 5 human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo and Vero). Compounds 7 and 8 exhibited cytotoxic activity against Lovo, with IC50 values of 18.7μM and 16.8μM, respectively.
从三角叶菝葜根茎中分离得到一个新的苯丙素苷和两个新的新木脂素，即(1S, 2R)-1-(3, 4, 5-三甲氧基苯基)-3-(β-D-吡喃葡萄糖氧基)-1, 2, 3-丙三醇(1)、(7R, 8R)-4, 7, 9, 9'-四羟基-3, 5, 3', 5'-四甲氧基-8-4'-氧新木脂素4-O-β-D-吡喃葡萄糖苷(2)和3', 9, 9'-三羟基-3, 5-二甲氧基-8-O-4'-新木脂素-
