葡萄糖转运蛋白 3 和 1 可能有助于胃 schwannoma 对 18F-FDG 的高摄取。

Glucose transporter 3 and 1 may facilitate high uptake of 18F-FDG in gastric schwannoma.

机构信息

From the *Department of Surgery and Science, and †Department of Pathology, Graduate School of Medicine & Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.

出版信息

Clin Nucl Med. 2013 Nov;38(11):e417-20. doi: 10.1097/RLU.0b013e318279f0d9.

DOI:10.1097/RLU.0b013e318279f0d9

PMID:24096997

Abstract

Recently, some gastric schwannomas have been reported to have high uptake of FDG. However, Glut-1 was reported to be negative in gastric schwannomas tested. A 64-year-old female patient received a laparoscopic partial gastrectomy for a FDG PET-positive submucosal tumor (SUVmax 6.61). The resected tumor was diagnosed as a benign gastric schwannoma. Glut family immunohistochemical examination revealed diffuse positive expression of Glut-3 and partial positive expression of Glut-1. On the other hand, Glut-2 and Glut-4 expression in the tumor were negative. This case suggested that Glut-3 and Glut-1 expression were facilitators of high FDG uptake in the benign gastric schwannoma.

摘要

最近，一些胃 schwannomas 被报道有较高的 FDG 摄取。然而，在测试的胃 schwannomas 中 Glut-1 被报道为阴性。一名 64 岁女性患者因 FDG PET 阳性的黏膜下肿瘤（SUVmax 6.61）接受了腹腔镜部分胃切除术。切除的肿瘤被诊断为良性胃 schwannoma。Glut 家族免疫组化检查显示 Glut-3 弥漫阳性表达，Glut-1 部分阳性表达。另一方面，肿瘤中 Glut-2 和 Glut-4 的表达为阴性。本病例提示 Glut-3 和 Glut-1 表达是良性胃 schwannoma 中 FDG 摄取增高的促进因素。